Association of one-point glucocorticoid-free status with chronic damage and disease duration in systemic lupus erythematosus: a cross-sectional study

Sada, Ken-ei; Katayama, Yu; Asano, Yosuke; Hayashi, Keigo; Miyawaki, Yoshia; Ohashi, Keiji; Katsuyama, Eri; Katsuyama, Takayuki; Takano-Narazaki, Mariko; Matsumoto, Yoshinori; Yoshimi, Ryusuke; Shimojima, Yasuhiro; Ohno, Shigeru; Kajiyama, Hiroshi; Ichinose, Kunihiro; Sato, Shuzo; Fujiwara, Michio; Yajima, Nobuyuki

doi:10.1136/lupus-2022-000772

Permalink : https://ousar.lib.okayama-u.ac.jp/65949

ID	65949
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Author	Sada, Ken-ei Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences ORCID Kaken ID researchmap Katayama, Yu Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Asano, Yosuke Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Hayashi, Keigo Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Miyawaki, Yoshia Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Ohashi, Keiji Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Katsuyama, Eri Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Katsuyama, Takayuki Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Takano-Narazaki, Mariko Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Matsumoto, Yoshinori Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Kaken ID researchmap Yoshimi, Ryusuke Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine Shimojima, Yasuhiro Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine Ohno, Shigeru Center for Rheumatic Diseases, Yokohama City University Medical Center Kajiyama, Hiroshi Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University Ichinose, Kunihiro Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences Sato, Shuzo Department of Rheumatology, Fukushima Medical University School of Medicine Fujiwara, Michio Department of Rheumatology, Yokohama Rosai Hospital Yajima, Nobuyuki Division of Rheumatology, Department of Medicine, Showa University School of Medicine
Abstract	Objective　It is still unclear how glucocorticoids (GCs) affect the long-term clinical course of patients with SLE. The objective of this study is to explore the factors associated with GC-free treatment status. Methods　Using data from the lupus registry of nationwide institutions, GC dose at registration was compared between short, middle and long disease durations of <5, 5–20 and ≥20 years, respectively. After excluding patients who never used GC, we evaluated the relationship between GC-free status and chronic damage using Systemic Lupus International Collaborating Clinics Damage Index. Results　GC doses at enrolment of the 1019 patients were as follows: GC-free in 101 (10%); 0 Conclusion　Even in the patients with long disease duration, one-point GC-free treatment status might be related to no chronic damage accrual.
Keywords	systemic lupus erythematosus glucocorticoids outcome assessment health care epidemiology
Published Date	2022-09-27
Publication Title	Lupus Science & Medicine
Volume	volume9
Issue	issue1
Publisher	BMJ
Start Page	e000772
ISSN	2053-8790
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© Author(s) (or their employer(s)) 2022.
File Version	publisher
PubMed ID	36167483
DOI	10.1136/lupus-2022-000772
Web of Science KeyUT	000861425300002
Related Url	isVersionOf https://doi.org/10.1136/lupus-2022-000772
License	http://creativecommons.org/licenses/by-nc/4.0/
Citation	Sada K, Katayama Y, Asano Y, et alAssociation of one-point glucocorticoid-free status with chronic damage and disease duration in systemic lupus erythematosus: a cross-sectional studyLupus Science & Medicine 2022;9:e000772. doi: 10.1136/lupus-2022-000772
Funder Name	Japan Society for the Promotion of Science
助成番号	JP19K1053