ID | 61032 |
FullText URL | |
Author |
Ueno, Hiroshi
Department of Medical Technology, Kawasaki University of Medical Welfare
Shimada, Atsumi
Division of Food and Nutrition, Nakamura Gakuen University Junior College
Suemitsu, Shunsuke
Department of Psychiatry, Kawasaki Medical School
Murakami, Shinji
Department of Psychiatry, Kawasaki Medical School
Kitamura, Naoya
Department of Psychiatry, Kawasaki Medical School
Wani, Kenta
Department of Psychiatry, Kawasaki Medical School
Takahashi, Yu
Department of Psychiatry, Kawasaki Medical School
Matsumoto, Yosuke
Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Okamoto, Motoi
Department of Medical Technology, Graduate School of Health Sciences, Okayama University
Kaken ID
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Ishihara, Takeshi
Department of Psychiatry, Kawasaki Medical School
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Abstract | Understanding the molecular and cellular mechanisms involved during the onset of epilepsy is crucial for elucidating the overall mechanism of epileptogenesis and therapeutic strategies. Previous studies, using a pentylenetetrazole (PTZ)-induced kindling mouse model, showed that astrocyte activation and an increase in perineuronal nets (PNNs) and extracellular matrix (ECM) molecules occurred within the hippocampus. However, the mechanisms of initiation and suppression of these changes, remain unclear.
Herein, we analyzed the attenuation of astrocyte activation caused by dizocilpine (MK-801) administration, as well as the anticonvulsant effect of α-pinene on seizures and production of ECM molecules. Our results showed that MK-801 significantly reduced kindling acquisition, while α-pinene treatment prevented an increase in seizures incidences. Both MK-801 and α-pinene administration attenuated astrocyte activation by PTZ and significantly attenuated the increase in ECM molecules.
Our results indicate that astrocyte activation and an increase in ECM may contribute to epileptogenesis and suggest that MK-801 and α-pinene may prevent epileptic seizures by suppressing astrocyte activation and ECM molecule production.
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Keywords | Epilepsy
Kindling
Pentylenetetrazol
Perineuronal nets
Wisteria floribunda
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Published Date | 2020
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Publication Title |
IBRO Reports
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Volume | volume9
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Publisher | Elsevier
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Start Page | 102
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End Page | 114
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ISSN | 2451-8301
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © 2020 The Author(s).
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File Version | publisher
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PubMed ID | |
DOI | |
Related Url | isVersionOf https://doi.org/10.1016/j.ibror.2020.07.007
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License | http://creativecommons.org/licenses/by-nc-nd/4.0/
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