ID | 69258 |
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Iguchi, Toshihiro
Department of Radiological Technology, Faculty of Health Sciences, Okayama University
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Nishikori, Asami
Department of Molecular Hematopathology, Okayama University Graduate School of Health Sciences
Sato, Yasuharu
Department of Molecular Hematopathology, Okayama University Graduate School of Health Sciences
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Nishimura, Midori Filiz
Department of Molecular Hematopathology, Okayama University Graduate School of Health Sciences
Iwaki, Noriko
Department of Hematology, National Cancer Center Hospital
Kojima, Katsuhide
Department of Radiology, Okayama University Hospital
Asahara, Takashi
Department of Radiological Technology, Faculty of Health Sciences, Okayama University
Otsuka, Fumio
Department of General Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Maeda, Yoshinobu
Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
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Hiraki, Takao
Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Abstract | This study retrospectively evaluated the computed tomography (CT) findings of idiopathic multicentric Castleman disease (iMCD) at a single center and compared the CT findings of iMCD-TAFRO with those of iMCD-non-TAFRO. CT images obtained within 30 days before diagnostic confirmation were reviewed for 20 patients with iMCD (8 men and 12 women, mean age 52.8 ± 12.3 years, range 25–74 years). Twelve patients were diagnosed with iMCD-TAFRO, five with iMCD-idiopathic plasmacytic lymphadenopathy, and three with iMCD-not otherwise specified. CT images revealed anasarca and lymphadenopathy in all 20 patients. The iMCD-TAFRO group showed significantly higher frequencies of ascites (100% vs. 37.5%, P = 0.004), gallbladder wall edema (75.0% vs. 12.5%, P = 0.020), periportal collar (91.7% vs. 25.0%, P = 0.004), and anterior mediastinal lesions (non-mass-forming infiltrative lesions) (66.7% vs. 12.5%, P = 0.028). Para-aortic edema tended to be more frequent in patients with the iMCD-TAFRO group (83.3% vs. 37.5%, P = 0.062), while the absence of anterior mediastinal lesions tended to be more frequent in the iMCD-non-TAFRO group (16.7% vs. 62.5%, P = 0.062). These CT findings may have clinical implications for improving the accuracy and speed of iMCD diagnosis and differentiating iMCD-TAFRO from other subtypes.
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Keywords | idiopathic multicentric Castleman disease
TAFRO syndrome
computed tomography
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Published Date | 2024-12-25
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Publication Title |
Journal of Clinical and Experimental Hematopathology
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Volume | volume64
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Issue | issue4
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Publisher | Japanese Society for Lymphoreticular Tissue Research
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Start Page | 292
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End Page | 296
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ISSN | 1346-4280
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NCID | AA11556796
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © 2024 by The Japanese Society for Lymphoreticular Tissue Research
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File Version | publisher
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Related Url | isVersionOf https://doi.org/001417179400004
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License | https://creativecommons.org/licenses/by-nc-sa/4.0/
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