| ID | 54603 |
| JaLCDOI | |
| FullText URL | |
| Author |
Maeda, Yoshinobu
Department of Hematology and Oncology, Okayama University Hospital
Kaken ID
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Nishimori, Hisakazu
Department of Hematology and Oncology, Okayama University Hospital
Kaken ID
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Inamoto, Yoshihiro
Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital
Nakamae, Hirohisa
Department of Hematology, Osaka City University Hospital
Sawa, Masashi
Department of Hematology and Oncology, Anjo Kosei Hospital
Mori, Yasuo
Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences
Ohashi, Kazuteru
Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center
Fujiwara, Shin-ichiro
Division of Hematology, Department of Medicine, Jichi Medical University
Tanimoto, Mitsune
Department of Hematology and Oncology, Okayama University Hospital
Kaken ID
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| Abstract | Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HSCT). Retinoic acid (tamibarotene) exerts multiple effects on cell differentiation and is clinically used for the treatment of acute promyelocytic leukemia. Tamibarotene down-regulates both Th1 and Th17 differentiation in donor T cells after allogeneic HSCT, resulting in attenuation of experimental chronic GVHD. Based on preclinical data, we have launched a phase II study of tamibarotene in patients with steroid-refractory chronic GVHD. This study will clarify whether tamibarotene can exert beneficial effects in patients with steroid-refractory chronic GVHD.
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| Keywords | Am80
tamibarotene
retinoid
chronic GVHD
steroid-refractory GVHD
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| Amo Type | Clinical Study Protocols
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| Publication Title |
Acta Medica Okayama
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| Published Date | 2016-10
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| Volume | volume70
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| Issue | issue5
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| Publisher | Okayama University Medical School
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| Start Page | 409
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| End Page | 412
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| ISSN | 0386-300X
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| NCID | AA00508441
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| Content Type |
Journal Article
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| language |
English
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| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School
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| File Version | publisher
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| Refereed |
True
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| PubMed ID | |
| Web of Science KeyUT |
