ID | 53518 |
FullText URL | |
Author |
Takatori, Shingo
Goda, Mitsuhiro
Iwatani, Yukiko
Jin, Xin
Takada-Doi, Shima
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Abstract | Royal jelly (RJ) is known to contain excellent nutrition and a variety of biological activities. The present study was designed to investigate the effects of RJ on insulin resistance (hyperinsulinemia) in fructose-drinking rats (FDR; insulin resistance animal model). Male Wistar rats (6 weeks old) received 15% fructose solution in drinking water for 8 weeks. FDR showed significant increases in plasma levels of insulin and triglyceride, Homeostasis Model Assessment ratio (HOMA-R, an index of insulin resistance), and systolic blood pressure, but not blood glucose levels, when compared with control rats. RJ (100, 300mg/kg, p.o.) treatment for 8 weeks significantly decreased the plasma levels of insulin and triglyceride, HOMA-R, without affecting blood glucose or total cholesterol levels and tended to lower systolic blood pressure. In isolated and perfused mesenteric vascular beds of FDR, RJ treatment resulted in a significant reduction in sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and tended to increase the calcitonin gene-related peptide (CGRP) nervemediated vasodilator response to PNS, compared with those in untreated FDR. However, RJ treatment did not significantly affect norepinephrine-induced vasoconstriction or CGRP-induced vasodilation. These results suggest that RJ could be an effective functional food to prevent insulin resistance associated with the development of hypertension.
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Keywords | royal jelly
fructose-drinking rat
insulin resistance
periarterial nerve function
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Note | コンテンツの著作権は日本薬学会が有します。
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Published Date | 2008-11-01
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Publication Title |
Biological & Pharmaceutical Bulletin
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Volume | volume31
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Issue | issue11
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Publisher | 日本薬学会
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Publisher Alternative | The Pharmaceutical Society of Japan
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Start Page | 2103
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End Page | 2107
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ISSN | 09186158
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NCID | AA10885497
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Content Type |
Journal Article
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language |
English
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Copyright Holders | © The Pharmaceutical Society of Japan
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File Version | publisher
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Refereed |
True
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DOI | |
PubMed ID | |
Web of Science KeyUT |