ID | 48716 |
FullText URL | |
Author |
Sakoda, Akihiro
Yoshimoto, Masaaki
Nakagawa, Shinya
Toyota, Teruaki
Nishiyama, Yuichi
Yamato, Keiko
Ishimori, Yuu
Taguchi, Takehito
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Abstract | Our previous studies showed the possibility that activation of the antioxidative function alleviates various oxidative damages, which are related to lifestyle diseases. Results showed that, low-dose X-ray irradiation activated superoxide dismutase and inhibits oedema following ischaemia-reperfusion. To alleviate ischaemia-reperfusion injury with transplantation, the changes of the antioxidative function in liver graft using low-dose X-ray irradiation immediately after exenteration were examined. Results showed that liver grafts activate the antioxidative function as a result of irradiation. In addition, radon inhalation enhances the antioxidative function in some organs, and alleviates alcohol-induced oxidative damage of mouse liver. Moreover, in order to determine the most effective condition of radon inhalation, mice inhaled radon before or after carbon tetrachloride (CCl4) administration. Results showed that radon inhalation alleviates CCl4-induced hepatopathy, especially prior inhalation. It is highly possible that adequate activation of antioxidative functions induced by low-dose irradiation can contribute to preventing or reducing oxidative damages, which are related to lifestyle diseases.
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Published Date | 2011-07
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Publication Title |
Radiation Protection Dosimetry
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Volume | volume146
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Issue | issue1-3
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Publisher | Oxford University Press
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Start Page | 360
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End Page | 363
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ISSN | 0144-8420
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NCID | AA10627673
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Content Type |
Journal Article
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Official Url | http://rpd.oxfordjournals.org/content/146/1-3/360.long
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language |
English
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Copyright Holders | © The Author 2011. Published by Oxford University Press. All rights reserved.
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File Version | publisher
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Refereed |
True
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DOI | |
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