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ID 16571
Eprint ID
16571
FullText URL
93_499.pdf 1.72 MB
Title Alternative
Studies on human peripheral monocyte chemotaxis Part II. Monocyte chemotaxis in patients with bronchogenic carcinoma
Author
Abstract
The chemotactic responsiveness of peripheral blood monocytes was measured in 71 patients with bronchogenic carcinoma, 13 patients with sarcoidosis, 14 patients with pulmonary tuberculosis and 91 normal controls. The monocyte chemotactic response (MCR) was significantly depressed in patients with bronchogenic carcinoma (mean=19.6±6.6,P<0.001) as compared to normal controls (mean=33.7±7.4). On the other hand, MCR was significantly enhanced in patients with pulmonary tuberculosis (mean=41.6±7.9,P<0.01). There was no significant difference from normal controls in patients with sarcoidosis (mean=27.5±8.5). In bronchogenic carcinoma patients, depression of the MCR was observed in all clinical stages. The MCR was further depressed in patients with evidence of distant metastasis compared to those without metastasis. There was no significant correlation between the MCR and histologic types of tumors. The MCR was significantly lowered by combination chemotherapy in 21 cases who received chemotherapy, but was elevated in 5 of 6 patients who had a remission after combination chemotherapy. These data showed that monocyte function in patients with bronchogenic carcinoma was suppressed, and suggested that malignant tumors themselves might affect monocyte function.
Keywords
monocyte
chemotaxis
bronchogenic carcinoma
chemotherapy
Published Date
1981-06-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume93
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
499
End Page
506
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/93/5-6/93_5-6_499/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma