ID | 52145 |
JaLCDOI | |
FullText URL | |
Author |
Terasaka, Tomohiro
Ueta, Eijiro
Ebara, Hirotaka
Waseda, Koichi
Kaken ID
Hanayama, Yoshihisa
publons
Kawabata, Tomoko
Kaken ID
Hidan, Ko
|
Abstract | A 64-year-old man suffering polyarthralgia and bone pain was referred to our hospital. Renal dysfunction,
hypophosphatemia and increased levels of bone alkaline phosphatase were found. The patientʼs serum creatinine level had gradually increased after the initiation of adefovir dipivoxil administration for hepatitis B. In agreement with multifocal uptakes of bone scintigraphy, iliac bone biopsy revealed an abnormal increase in osteoid tissues. Reducing the dose of adefovir and initiating the administration of eldecalcitol were effective for reducing proteinuria and glucosuria, and for ameliorating bone pain with an increase in serum phosphate level. This case first showed a clinical course of hypophosphatemic osteomalacia caused by secondary Fanconiʼs syndrome for 8 years after adefovir administration. Early diagnosis is important for the reversibility of bone damage and for a better renal prognosis.
|
Keywords | adefovir dipivoxil (ADV)
eldecalcitol
Fanconi's syndrome
hypophosphatemia
osteomalacia
|
Amo Type | Case Report
|
Publication Title |
Acta Medica Okayama
|
Published Date | 2014-02
|
Volume | volume68
|
Issue | issue1
|
Publisher | Okayama University Medical School
|
Start Page | 53
|
End Page | 56
|
ISSN | 0386-300X
|
NCID | AA00508441
|
Content Type |
Journal Article
|
language |
English
|
Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School
|
File Version | publisher
|
Refereed |
True
|
PubMed ID |