ID | 55301 |
FullText URL | |
Author |
Itoh, Hideshi
Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Ichiba, Shing
Department of Community and Emergency Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Ujike, Yoshihito
Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Douguchi, Takuma
Arai, Sadahiko
Department of Cardiovascular Surgery, Okayama University Hospital
Sano, Shunji
Department of Cardiovascular Surgery, Okayama University Hospital
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Abstract | OBJECT:
We compared the clinical effectiveness and biocompatibility of poly-2-methoxyethyl acrylate (PMEA)-coated and heparin-coated cardiopulmonary bypass (CPB) circuits in a prospective pediatric trial.
METHODS:
Infants randomly received heparin-coated (n=7) or PMEA-coated (n=7) circuits in elective pediatric cardiac surgery with CPB for ventricular septum defects. Clinical and hematologic variables, respiratory indices and hemodynamic changes were analyzed perioperatively.
RESULTS:
Demographic and clinical variables were similar in both groups. Leukocyte counts were significantly lower 5 minutes after CPB in the PMEA group than the heparin group. Hemodynamic data showed that PMEA caused hypotension within 5 minutes of CPB. The respiratory index was significantly higher immediately after CPB and 1 hour after transfer to the intensive care unit (ICU) in the PMEA group, as were levels of C-reactive protein 24 hours after transfer to the ICU.
CONCLUSION:
Our study shows that PMEA-coated circuits, unlike heparin-coated circuits, cause transient leukopenia during pediatric CPB and, perhaps, systemic inflammatory respiratory syndrome after pediatric CPB.
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Keywords | PMEA coating
cardiopulmonary bypass
heparin coating
pediatric
transient leukopenia
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Note | 学位審査副論文
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Published Date | 2016-04
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Publication Title |
Perfusion
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Volume | volume31
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Issue | issue3
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Publisher | Sage
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Start Page | 247
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End Page | 254
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ISSN | 0267-6591
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NCID | AA10674287
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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File Version | author
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
Related Url | https://doi.org/10.1177/0267659115598217
http://ousar.lib.okayama-u.ac.jp/54282
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