ID | 13929 |
Eprint ID | 13929
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FullText URL | |
Title Alternative | Thermotolerance induction by benzalkonium chloride in NIH3T3 cells
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Author |
Nishikawa, Koji
Tanaka, Seiryo
Gao, Xian Shu
Yamamoto, Michinori
Makihata, Eiichi
Hiraki, Yoshio
Kawasaki, Shoji
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Abstract | The ability of benzalkonium chloride to induce thermotolerance was examined in NIH3T3 cells. Benzalkonium chloride enhanced cytotoxicity as its concentration and administration period increased. The cell survival decreased to 50% of that in the non-treated group by 20min of treatment in 0.002% benzalkonium chloride. Thermotolerance developed during the culture after 20min of treatment with 0.002% benzalkonium chloride. Thermotolerance reached its peak at 15h after treatment and decreased subsequently. At 15h after treatment, the Do value at 45℃ heating, a parameter of thermotolerance was 3.8-fold higher than that of the non-treated group. The thermotolerance induced by 0.002% benzalkonium chloride increased as its treatment period was prolonged. These findings suggested a relationship between thermotolerance induction and the cell membrane damage by benzalkonium chloride.
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Keywords | 温熱療法
温熱耐性
塩化ベンザルコニウム
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Published Date | 1993-02
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Publication Title |
岡山医学会雑誌
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Publication Title Alternative | Journal of Okayama Medical Association
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Volume | volume105
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Issue | issue1-2
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Publisher | 岡山医学会
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Publisher Alternative | Okayama Medical Association
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Start Page | 43
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End Page | 48
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ISSN | 0030-1558
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NCID | AN00032489
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Content Type |
Journal Article
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Official Url | https://www.jstage.jst.go.jp/article/joma1947/105/1-2/105_1-2_43/_article/-char/ja/
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Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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language |
Japanese
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Copyright Holders | 岡山医学会
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File Version | publisher
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Refereed |
True
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Eprints Journal Name | joma
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