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ID 30398
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Author
Moriyama, Masahiro
Domoto, Haruyo
Yamashita, Syoichi
Furuno, Katsushi
Oishi, Ryozo
Kawasaki, Hiromu Kaken ID publons
Gomita, Yutaka
Abstract

We examined the pharmacokinetics of phenobarbital before and during pregnancy in rats. Animals were divided into four groups: (a) control, (b) pregnant, (c) phenobarbital-treated, and (d) phenobarbital-treated pregnant groups. The increase in body weight of nonpregnant or pregnant rats was not influenced by long-term phenobarbital treatment. Plasma phenobarbital concentrations during the period of long-term phenobarbital treatment with a fixed dosage by body weight were not significantly affected by pregnancy. Furthermore, pregnancy did not affect pharmacokinetic parameters of phenobarbital between 0.25 and 24h after administration. These results suggest that pregnancy does not influence on the pharmacokinetics of long-term phenobarbital treatment at a fixed dosage by body weight.

Keywords
phenobarbital
pharmacokinetics
pregnancy
plasma concentrations
Amo Type
Article
Publication Title
Acta Medica Okayama
Published Date
1995-10
Volume
volume49
Issue
issue5
Publisher
Okayama University Medical School
Start Page
237
End Page
240
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT