ID | 14170 |
Eprint ID | 14170
|
FullText URL | |
Title Alternative | Studies on the mechanism and treatment of intractable asthma Part 2. The mechanism of specific thromboxane A(2) synthetase inhibitor in cell-mediated allergy in intractable asthmatics
|
Author | |
Abstract | The specific thromboxane A(2) (TXA(2)) synthetase inhibitor (OKY-046) seems to be a useful drug in the treatment of intractable asthmatics. In this study, to clarify the action mechanism of OKY-046 and the relationship between TXA(2) and prostaglandin E(2) (PGE(2)) in cell-mediated allergy, the effect of the TXA(2) receptor antagonist (AA-2414), TXA2 analogue (STA(2)) and PGE(2) for peripheral blood mononuclear cells in adult intractable asthmatics was studied. OKY-046 significantly suppressed TXB(2) production and increased PGE(2) production from the peripheral blood mononuclear cells stimulated by PHA and Candida antigen, but AA-2414 had no effect. AA-2414 suppressed lymphocyte blastgenesis, but did not suppress significantly interleukin-2 (IL-2) or neutrophil chemotactic factor (NCF) production. Furthermore, STA(2) increased lymphocyte blastgenesis stimulated by Candida antigen partially, but not dose-dependently. On the other hand, PGE(2) suppressed significantly lymphocyte blastgenesis and IL-2 and NCF production in a dose-dependent manner. These findings suggest that the action mechanism of OKY-046 is a suppressive effect of cell-mediated allergy, and that TXA(2) and PGE(2) play an important role in the mechanism of intractable asthma.
|
Keywords | Intractable asthma
thromboxane A(2)
prostaglandin E(2)
thromboxane A(2) synthetase inhibitor (OKY-046)
thromboxane A(2) receptor antagonist (AA-2414)
|
Note | 原著
|
Published Date | 1992-08
|
Publication Title |
岡山医学会雑誌
|
Publication Title Alternative | Journal of Okayama Medical Association
|
Volume | volume104
|
Issue | issue7-8
|
Publisher | 岡山医学会
|
Publisher Alternative | Okayama Medical Association
|
Start Page | 735
|
End Page | 746
|
ISSN | 0030-1558
|
NCID | AN00032489
|
Content Type |
Journal Article
|
Official Url | https://www.jstage.jst.go.jp/article/joma1947/104/7-8/104_7-8_735/_article/-char/ja/
|
Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
|
language |
Japanese
|
Copyright Holders | 岡山医学会
|
File Version | publisher
|
Refereed |
True
|
Eprints Journal Name | joma
|