ID | 10576 |
Eprint ID | 10576
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FullText URL | |
Title Alternative | Induction of Atherosclerosis in Aorta and Coronary Artery of Chicken by Orally Administered Cholesterol
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Author |
Honjo, Sachika
Ohtsuki, Kazumasa
Abe, Asaki
researchmap
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Abstract | Hypercholesterolemia and hyperlipidemia have been important in human health as factors that induce atherosclerotic lesions in brain and heart blood vessel. Various experimental studies have been done to prevent and treat atherosclerotic lesions in animals. In the present study, we assessed the suitability of chickens as experimental animal for atherosclerosis. Newly hatched chicks were fed on 1.0%-or 0.1%-cholesterol(CHO) containing feed. After 3 and 6 months, total cholesterol levels in the sera and histological changes in the aorta and coronary artery of chicks fed on 1.0%-CHO-containing feed for 3 and 6 months, intimal thickening and marked accumulation of foam cells were observed. Endothelial cells had disappeared in the aorta of these chicks. A slight accumulation of foam cells was observed in the aortic intima of chicks fed on 0.1%-CHO-containing feed. In the coronary artery, a remarkable thickening of intima with accumulation of foam cells and a marked stenosis of coronary space were observed in chicks fed on 1.0%-CHO-containing feed. The results of present study indicate that the chicken can be a useful experimental animal in the study of hypercholesterolemia, hyperlipidemia and atherosclerosis.
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Keywords | experimental atherosclerosis
cholrsterol
chicks
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Published Date | 2004-02
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Publication Title |
岡山大学農学部学術報告
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Publication Title Alternative | Scientific reports of the Faculty of Agriculture, Okayama University
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Volume | volume93
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Issue | issue1
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Publisher | 岡山大学農学部
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Publisher Alternative | Faculty of Agriculture,Okayama University
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Start Page | 45
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End Page | 49
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ISSN | 0474-0254
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NCID | AN00033029
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Content Type |
Departmental Bulletin Paper
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language |
Japanese
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File Version | publisher
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Refereed |
False
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Eprints Journal Name | srfa
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