| FullText URL | fulltext.pdf |
|---|---|
| Author | Kanzaki, Yuki| Fujita, Hirofumi| Sato, Keita| Hosokawa, Mio| Matsumae, Hiroshi| Shiraga, Fumio| Morizane, Yuki| Ohuchi, Hideyo| |
| Keywords | Kir7.1 KCNJ13 human-induced pluripotent cells retinal pigment epithelium phagocytosis |
| Published Date | 2020-05 |
| Publication Title | Investigative Ophthalmology & Visual Science |
| Volume | volume61 |
| Issue | issue5 |
| Publisher | Association for Research in Vision and Ophthalmology |
| Start Page | 38 |
| ISSN | 0146-0404 |
| NCID | AA00683736 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | Copyright 2020 The Authors |
| File Version | publisher |
| PubMed ID | 32437550 |
| DOI | 10.1167/iovs.61.5.38 |
| Web of Science KeyUT | 000540905500039 |
| Related Url | isVersionOf https://doi.org/10.1167/iovs.61.5.38 |
| JaLCDOI | 10.18926/AMO/57716 |
|---|---|
| FullText URL | 73_6_517.pdf |
| Author | Hosogi, Mika| Shiode, Yusuke| Morizane, Yuki| Kimura, Shuhei| Hosokawa, Mio| Doi, Shinichiro| Toshima, Shinji| Takahashi, Kosuke| Fujiwara, Atsushi| Shiraga, Fumio| |
| Abstract | We investigated the effectiveness of a treat-and-extend regimen (TAE) of intravitreal ranibizumab injections for macular edema (ME) due to branch retinal vein occlusion (BRVO). We retrospectively examined 2-year results of 32 eyes of 32 patients who underwent TAE to treat ME due to BRVO. The patients whose treatment interval extended to ≥ 12 weeks were switched to a pro re nata regimen (PRN). For the patients whose treatment interval was <12 weeks, TAE was continued. At 2 years, 10 eyes had required no additional injections after the initial treatment period [recurrence(−) group], whereas the other 22 eyes required additional treatment [recurrence(+) group]. Among the recurrence(+) patients, 11 eyes (34.4% of total) were eventually switched from TAE to PRN; the other 11 eyes (34.4%) continued TAE for 2 years. Visual acuity and central retinal thickness were significantly improved in both the recurrence(+) and (−) groups, and there was no significant betweengroup difference in visual acuity at 2 years. Univariate analyses revealed significant differences in visual acuity (p=0.004), age (p=0.014), and vessel occlusion site (p=0.018) between these groups. Our results suggest that TAE may be effective for BRVO patients with lower visual acuity, older age, and occlusion of a major vein. |
| Keywords | branch retinal vein occlusion macular edema anti-vascular endothelial growth factor ranibizumab treat-and-extend regimen |
| Amo Type | Original Article |
| Published Date | 2019-12 |
| Publication Title | Acta Medica Okayama |
| Volume | volume73 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 517 |
| End Page | 522 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31871334 |
| Web of Science KeyUT | 000503431400007 |
| JaLCDOI | 10.18926/AMO/53028 |
|---|---|
| FullText URL | 68_6_379.pdf |
| Author | Doi, Shinichiro| Kimura, Shuhei| Morizane, Yuki| Hosogi, Mika| Hosokawa, Mio| Shiode, Yusuke| Kawata, Tetsuhiro| Kondo, Eisei| Shiraga, Fumio| |
| Abstract | We report a case of POEMS syndrome in a 20-year-old patient diagnosed after visiting an eye clinic with a chief complaint of reduced visual acuity. A male university student aged 20 years was referred to our department complaining of blurred vision in both eyes that had persisted for 1 month. He also noted headache, nausea, and paresthesia in the lower extremities around the same time. The visual acuity of his right and left eye was 20/40 and 20/20, respectively. Optic disc edema and serous retinal detachment were present. Brain magnetic resonance imaging showed no intracranial abnormalities, while elevated cerebrospinal fluid pressure, reduced nerve conduction velocity in both lower extremities, hepatosplenomegaly, M proteinemia, high blood VEGF levels, osteoblastic and osteolytic changes in the spine, and atypical plasma cells in bone lesions were noted. From the above findings, the patient was diagnosed with POEMS syndrome. He received high-dose dexamethasone, thalidomide, and radiotherapy on the sacral mass, followed by high-dose melphalan with autologous stem-cell support, and showed subsequent systemic and ophthalmologic improvement. Here, we report the youngest case ever of POEMS syndrome with ocular manifestation. If patients have optic disc edema in both eyes with no intracranial space-occupying lesion, POEMS syndrome should be considered in differential diagnosis, regardless of age. |
| Keywords | POEMS syndrome serous retinal detachment VEGF |
| Amo Type | Case Report |
| Published Date | 2014-12 |
| Publication Title | Acta Medica Okayama |
| Volume | volume68 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 379 |
| End Page | 383 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25519033 |
| Web of Science KeyUT | 000346882200009 |
