ID | 58754 |
FullText URL | |
Author |
Han, Yanyan
Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
ORCID
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Abstract | Cancer is a serious health issue in the world due to a large body of cancer-related human deaths, and there is no current treatment available to efficiently treat the disease as the tumor is often diagnosed at a serious stage. Moreover, Cancer cells are often resistant to chemotherapy, radiotherapy, and molecular-targeted therapy. Upon further knowledge of mechanisms of tumorigenesis, aggressiveness, metastasis, and resistance to treatments, it is necessary to detect the disease at an earlier stage and for a better response to therapy. The hippo pathway possesses the unique capacity to lead to tumorigenesis. Mutations and altered expression of its core components (MST1/2, LATS1/2, YAP and TAZ) promote the migration, invasion, malignancy of cancer cells. The biological significance and deregulation of it have received a large body of interests in the past few years. Further understanding of hippo pathway will be responsible for cancer treatment. In this review, we try to discover the function of hippo pathway in different diversity of cancers, and discuss how Hippo pathway contributes to other cellular signaling pathways. Also, we try to describe how microRNAs, circRNAs, and ZNFs regulate hippo pathway in the process of cancer. It is necessary to find new therapy strategies for cancer.
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Keywords | Hippo pathway
YAP/TAZ
Cancer
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Published Date | 2019-08-08
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Publication Title |
Journal of Translational Medicine
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Volume | volume17
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Publisher | Springer
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Start Page | 116
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ISSN | 14795876
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NCID | AA12051092
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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File Version | publisher
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PubMed ID | |
DOI | |
Related Url | isVersionOf https://doi.org/10.1186/s12967-019-1869-4
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License | http://creativecommons.org/licenses/by/4.0/
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