ID | 62753 |
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Author |
Abe, Kodai
Department of Surgery, Keio University School of Medicine
Kitago, Minoru
Department of Surgery, Keio University School of Medicine
Kitagawa, Yuko
Department of Surgery, Keio University School of Medicine
Hirasawa, Akira
Department of Clinical Genomic Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Kaken ID
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Abstract | Pancreatic cancer is associated with both family and hereditary cancer syndromes. Multigene panel testing for pancreatic cancer detected the germline variants BRCA1/2, PALB2, ATM, TP53, MLH1, STK11/LKB1, APC, CDKN2A, and SPINK1/ PRSS1 as high-risk genes. A latest genome-wide association study revealed the common, but low-risk germline variants in pancreatic cancer patients. Active pancreatic surveillance using magnetic resonance imaging and endoscopic ultrasound is recommended for high-risk individuals who have a family history of pancreatic cancer or harbor these germline pathogenic variants to improve the detection rate and prognosis of pancreatic cancer. Since poly-ADP-ribose polymerase (PARP) inhibitor has been shown to be effective in improving the prognosis of BRCA -positive pancreatic cancer as well as hereditary breast and ovarian cancer syndrome, PARP inhibitor therapy is currently being applied as precision medicine to pancreatic cancer patients harboring the BRCA1/2 germline variant. This review highlights the importance of surveillance for germline pathogenic variants in pancreatic cancer and is expected to lead to improvements in the diagnosis and prevention of pancreatic cancer as well as facilitate the development of effective therapeutic strategies and precision medicine.
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Keywords | Cancer predisposition gene
Familial pancreatic cancer
Hereditary pancreatic cancer
Multigene panel
testing
Surveillance
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Published Date | 2021-9-2
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Publication Title |
International Journal of Clinical Oncology
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Volume | volume26
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Issue | issue10
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Publisher | Springer Science and Business Media LLC
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Start Page | 1784
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End Page | 1792
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ISSN | 1341-9625
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © The Author(s) 2021
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File Version | publisher
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DOI | |
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Related Url | isVersionOf https://doi.org/10.1007/s10147-021-02015-6
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License | https://creativecommons.org/licenses/by/4.0
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Citation | Abe, K., Kitago, M., Kitagawa, Y. et al. Hereditary pancreatic cancer. Int J Clin Oncol 26, 1784–1792 (2021). https://doi.org/10.1007/s10147-021-02015-6
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Funder Name |
Ministry of Health, Labour and Welfare, Japan
Foundation for Promotion of Cancer, Research in Japan
Daiwa Securities Health Foundation
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助成番号 | 20EA1027
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