Author Kataoka, Yuko| Fukushima, Kunihiro| Sugaya, Akiko| Nishizaki, Kazunori|
Published Date 2012-08-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue2
Content Type Journal Article
Author Kawasaki, Akihiro| Fukushima, Kunihiro| Kataoka, Yuko| Fukuda, Shoichiro| Nishizaki, Kazunori|
Published Date 2006-8
Publication Title International Journal of Pediatric Otorhinolaryngology
Volume volume70
Issue issue8
Content Type Journal Article
JaLCDOI 10.18926/AMO/32023
FullText URL fulltext.pdf
Author Sugata, Ken-ichi| Fukushima, Kunihiro| Ogawa, Teruhiro| Nakashima, Tomoko| Sugata, Akemi| Kasaki, Norio| Gunduz, Mehmet|
Abstract <p>The prevalence of penicillin non-susceptible Streptococcus pneumoniae (PNSSP) is increasing among isolates from acute otitis media (AOM). Repeated episodes of antibiotic exposure are a well-known risk factor for the isolation of PNSSP although otitis-prone or recurrent AOM cases frequently require repeated courses of antibiotic treatment. In order to evaluate the chronological alteration of S. pneumoniae during recurrences of AOM, strains of S. pneumoniae were isolated from 11 patients, each of whom had experienced 2-4 episodes of AOM, were examined. Every bacterial specimen obtained from a single episode of recurrent AOM was examined by PCR-based penicillin-binding protein (PBP) assay, serotyping, and amplified fragment length polymorphism (AFLP), then compared to other samples from the same case. Two cases (18.2%) showed strain diversity during repeated antibiotic treatments by serotyping or PBP-assay. By AFLP analysis, 6 cases (54.5%) demonstrated heterogeneous strains during recurrent AOM. Clonal survivors of previous episodes of AOM were not always the cause of subsequent episodes of AOM, even in otitis-prone cases.</P></p>
Keywords acute otitis media amplified fragment length polymorphism(AFLP) penicillin non-susceptible Streptococcus pncumoniac.
Amo Type Article
Published Date 2001-06
Publication Title Acta Medica Okayama
Volume volume55
Issue issue3
Publisher Okayama University Medical School
Start Page 167
End Page 174
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 11434429
Web of Science KeyUT 000169512600003
Author Watanabe, Shuichi| Kawakami, Takashi| Inokuchi, Ikuo| Uno, Kin-ya| Ohomichi, Takuya| Fukazawa, Motoharu| Yoneda, Takaaki| Fukushima, Kunihiro| Masuda, Yu| Kamikawa, Yasuaki|
Published Date 1992
Publication Title 岡山医学会雑誌
Volume volume104
Issue issue1-2
Content Type Journal Article
Author 福島 邦博|
Published Date 1994-03-25
Publication Title
Content Type Thesis or Dissertation