JaLCDOI | 10.18926/AMO/32840 |
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FullText URL | fulltext.pdf |
Author | Abe, Asaki| Kawasoe, Chiaki| Kondo, Yasuhiro| Sato, Katsunori| |
Abstract | Changes in norepinephrine-induced transient contractions in Ca2+-deficient solution were investigated in the aortic smooth muscles of diabetic ALS (alloxan-induced diabetes susceptible) mice. The transient contractions in diabetic mice were significantly larger than those in normal mice. The longer incubation of the muscle preparations in Ca2+-deficient solution made the transient contractions smaller, probably due to the leakage and decrease in norepinephrine-releasable stored Ca2+. The rate of this reduction in contraction was slower in diabetic mice. These results suggest that the leakage of intracellular stored Ca2+ caused by extracellular Ca2+ deficiency is attenuated in diabetic mice, contributing to enhanced norepinephrine-induced transient contractions. |
Keywords | diabetes mellitus vascular smooth muscle norepinephrine |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2003-02 |
Volume | volume57 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 45 |
End Page | 48 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 12765224 |
Web of Science KeyUT | 000181198200007 |
Author | Nagato, Kumiko| Abe, Asaki| Narabara, Kiyoaki| Kondo, Yasuhiro| |
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Published Date | 2009-02 |
Publication Title | 岡山大学農学部学術報告 |
Volume | volume98 |
Issue | issue1 |
Content Type | Departmental Bulletin Paper |
Author | Kondo, Yasuhiro| Honjo, Sachika| Ohtsuki, Kazumasa| Abe, Asaki| |
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Published Date | 2004-02 |
Publication Title | 岡山大学農学部学術報告 |
Volume | volume93 |
Issue | issue1 |
Content Type | Departmental Bulletin Paper |
Author | Han, Song| Abe, Asaki| Narahara, Kiyoaki| Kondo, Yasuhiro| |
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Published Date | 2007-02 |
Publication Title | 岡山大学農学部学術報告 |
Volume | volume96 |
Issue | issue1 |
Content Type | Departmental Bulletin Paper |