| ID | 54608 |
| JaLCDOI | |
| FullText URL | |
| Author |
Asano, Takeru
Department of Hematology and Oncology, Okayama University Hospital
Matsuoka, Ken-ichi
Department of Hematology and Oncology, Okayama University Hospital
ORCID
Kaken ID
Iyama, Satoshi
Department of Medical Oncology and Hematology, Sapporo Medical University Hospital
Ohashi, Kazuteru
Hematology division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
Inamoto, Yoshihiro
Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital
Ohwada, Chikako
Department of Hematology, Chiba University Hospital
Murata, Makoto
Department of Hematology and Oncology, Nagoya University Graduate School of Medicine
Satake, Atsushi
First Department of Internal Medicine, Kansai Medical University
Yoshida, Chikamasa
Division of Hematology, National Hospital Organization Minami-Okayama Medical Center
Nakase, Koichi
Division of Hematology, Ehime Prefectural Central Hospital
Mori, Yasuo
Department of Hematology and Oncology, Kyushu University Hospital
Tanimoto, Mitsune
Department of Hematology and Oncology, Okayama University Hospital
Kaken ID
publons
researchmap
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| Abstract | Chronic graft versus host disease (cGVHD) remains a major problem for long survivors after allogeneic hematopoietic stem cell transplantation (HSCT). Currently, corticosteroid therapy is effective for cGVHD as the first line therapy. However, prolonged therapy with corticosteroids causes various severe adverse events. To develop the new therapeutic strategy of cGVHD, we have launched a multicenter phase I/IIa clinical trial of low dose subcutaneous interleukin-2 (IL-2) for treatment of steroid refractory cGVHD, which is constituted of 2 sequential phases (induction phase and maitanance phase). This study will provide the new therapeutic option for patients with refractory cGVHD after allogeneic HSCT.
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| Keywords | chronic GVHD
allogeneic HSCT
steroid refractory
IL-2
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| Amo Type | Clinical Study Protocols
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| Publication Title |
Acta Medica Okayama
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| Published Date | 2016-10
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| Volume | volume70
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| Issue | issue5
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| Publisher | Okayama University Medical School
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| Start Page | 429
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| End Page | 433
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| ISSN | 0386-300X
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| NCID | AA00508441
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| Content Type |
Journal Article
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| language |
English
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| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School
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| File Version | publisher
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| Refereed |
True
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| PubMed ID | |
| Web of Science KeyUT |
