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Asano, Takeru Department of Hematology and Oncology, Okayama University Hospital
Matsuoka, Ken-ichi Department of Hematology and Oncology, Okayama University Hospital
Iyama, Satoshi Department of Medical Oncology and Hematology, Sapporo Medical University Hospital
Ohashi, Kazuteru Hematology division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
Inamoto, Yoshihiro Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital
Ohwada, Chikako Department of Hematology, Chiba University Hospital
Murata, Makoto Department of Hematology and Oncology, Nagoya University Graduate School of Medicine
Satake, Atsushi First Department of Internal Medicine, Kansai Medical University
Yoshida, Chikamasa Division of Hematology, National Hospital Organization Minami-Okayama Medical Center
Nakase, Koichi Division of Hematology, Ehime Prefectural Central Hospital
Mori, Yasuo Department of Hematology and Oncology, Kyushu University Hospital
Tanimoto, Mitsune Department of Hematology and Oncology, Okayama University Hospital
Abstract
Chronic graft versus host disease (cGVHD) remains a major problem for long survivors after allogeneic hematopoietic stem cell transplantation (HSCT). Currently, corticosteroid therapy is effective for cGVHD as the first line therapy. However, prolonged therapy with corticosteroids causes various severe adverse events. To develop the new therapeutic strategy of cGVHD, we have launched a multicenter phase I/IIa clinical trial of low dose subcutaneous interleukin-2 (IL-2) for treatment of steroid refractory cGVHD, which is constituted of 2 sequential phases (induction phase and maitanance phase). This study will provide the new therapeutic option for patients with refractory cGVHD after allogeneic HSCT.
Keywords
chronic GVHD
allogeneic HSCT
steroid refractory
IL-2
Amo Type
Clinical Study Protocols
Published Date
2016-10
Publication Title
Acta Medica Okayama
Volume
volume70
Issue
issue5
Publisher
Okayama University Medical School
Start Page
429
End Page
433
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2016 by Okayama University Medical School
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publisher
Refereed
True
PubMed ID
Web of Sience KeyUT