| FullText URL | fulltext.pdf |
|---|---|
| Author | Sasaki, Takanori| Kimura, Sadaaki| Noda, Akihiro| Murakami, Yoshihiro| Miyoshi, Sosuke| Akehi, Masaru| Ochiai, Kazuhiko| Watanabe, Masami| Higuchi, Takahiro| Matsuura, Eiji| |
| Keywords | PET imaging Zirconium-89 Therapeutic antibodies Non-human primates |
| Published Date | 2025-05 |
| Publication Title | Nuclear Medicine and Biology |
| Volume | volume144-145 |
| Publisher | Elsevier BV |
| Start Page | 109001 |
| ISSN | 0969-8051 |
| NCID | AA10864894 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Authors. |
| File Version | publisher |
| PubMed ID | 39985867 |
| DOI | 10.1016/j.nucmedbio.2025.109001 |
| Web of Science KeyUT | 001432539500001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.nucmedbio.2025.109001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Saito, Yukihiro| Nose, Naoko| Iida, Toshihiro| Akazawa, Kaoru| Kanno, Takayuki| Fujimoto, Yuki| Sasaki, Takanori| Akehi, Masaru| Higuchi, Takahiro| Akagi, Satoshi| Yoshida, Masashi| Miyoshi, Toru| Ito, Hiroshi| Nakamura, Kazufumi| |
| Keywords | sodium/iodide symporter human induced pluripotent stem cell-derived cardiomyocytes single photon emission computed tomography cell-based therapy in vivo imaging |
| Published Date | 2023-09-07 |
| Publication Title | Frontiers in Cardiovascular Medicine |
| Volume | volume10 |
| Publisher | Frontiers Media |
| Start Page | 1261330 |
| ISSN | 2297-055X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Saito, Nose, Iida, Akazawa, Kanno, Fujimoto, Sasaki, Akehi, Higuchi, Akagi, Yoshida, Miyoshi, Ito and Nakamura. |
| File Version | publisher |
| PubMed ID | 37745108 |
| DOI | 10.3389/fcvm.2023.1261330 |
| Web of Science KeyUT | 001069842100001 |
| Related Url | isVersionOf https://doi.org/10.3389/fcvm.2023.1261330 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fithroni, Abdul Basith| Kobayashi, Kazuko| Uji, Hirotaka| Ishimoto, Manabu| Akehi, Masaru| Ohtsuki, Takashi| Matsuura, Eiji| |
| Keywords | boron neutron capture therapy (BNCT) biologically self-degradable amphipathic polymer (Lactosome) hydrophobic boron cluster carborane isomers or o-carborane alkylated derivatives molecular glue effect |
| Published Date | 2022-10-21 |
| Publication Title | CELLS |
| Volume | volume11 |
| Issue | issue20 |
| Publisher | MDPI |
| Start Page | 3307 |
| ISSN | 2073-4409 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 36291173 |
| DOI | 10.3390/cells11203307 |
| Web of Science KeyUT | 000872497500001 |
| Related Url | isVersionOf https://doi.org/10.3390/cells11203307 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Lim, Melissa Siaw Han| Ohtsuki, Takashi| Takenaka, Fumiaki| Kobayashi, Kazuko| Akehi, Masaru| Uji, Hirotaka| Kobuchi, Hirotsugu| Sasaki, Takanori| Ozeki, Eiichi| Matsuura, Eiji| |
| Keywords | theranostics single chain variable fragment of IgG (scFv) drug delivery system (DDS) photodynamic therapy (PDT) PET imaging accelerated blood clearance (ABC) cell penetrating peptide (CPP) siRNA ATP-binding cassette subfamily G member 2 (ABCG2) |
| Published Date | 2021-02-18 |
| Publication Title | Life |
| Volume | volume11 |
| Issue | issue2 |
| Publisher | MDPI |
| Start Page | 158 |
| ISSN | 2075-1729 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| PubMed ID | 33670777 |
| DOI | 10.3390/life11020158 |
| Web of Science KeyUT | 000622756700001 |
| Related Url | isVersionOf https://doi.org/10.3390/life11020158 |
| JaLCDOI | 10.18926/AMO/53999 |
|---|---|
| FullText URL | 70_1_13.pdf |
| Author | Arum Tri Wahyuningsih| Shen, Lianhua| Kobayashi, Kazuko| Sasaki, Takanori| Takenaka, Fumiaki| Hanada, Takahisa| Akehi, Masaru| Akahoshi, Akiya| Ozeki, Eiichi| Ando, Eiji| Matsuura, Eiji| |
| Abstract | Intact β2-glycoprotein I (iβ2GPI) is a glycoprotein that regulates coagulation and fibrinolysis. Nicked β2GPI (nβ2GPI) possesses an angiogenic property at a relatively low concentration, and an antiangiogenic property at a high concentration. Here we investigated the functions of βi 2GPI and nβ2GPI in vascular endothelial growth factor (VEGF)-A-induced endothelial cell proliferation and tube formation. We used noninvasive PET imaging to analyze the in vivo distribution of intravenously injected β2GPI variants in tumor lesions in mice. iβ2GPI was incubated with plasmin to obtain nβ2GPI, and its N-terminal sequence was analyzed. nβ2GPI had at least one other cleavage site upstream of the β2GPIʼs domain V, whereas the former plasmin-cleavage site locates between K317 and T318. Both of intact and nicked β2GPI significantly inhibited the VEGF-A-induced cell proliferation and the tube formation of human umbilical vein endothelial cells (HUVECs). PET imaging visualized considerably distributed intensities of all tested β2GPI variants in tumor lesions of pancreatic tumor cell-xenografts. These results indicate that β2GPI may be physiologically and pathophysiologically important in the regulation of not only coagulation and fibrinolysis, but also angiogenesis. |
| Keywords | β2-glycoprotein I (β2GPI) angiogenesis vascular endothelial growth factor-A (VEGF-A) positron emission tomography (PET) imaging |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-02 |
| Volume | volume70 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 13 |
| End Page | 24 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26899605 |
| Web of Science KeyUT | 000371288700002 |
