Araki, Motoo - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

ROS produced by Dual oxidase regulate cell proliferation and haemocyte migration during leg regeneration in the cricket

FullText URL	fulltext.pdf
Author	Okumura-Hirono, Misa\| Bando, Tetsuya\| Hamada, Yoshimasa\| Araki, Motoo\| Ohuchi, Hideyo\|
Keywords	Regeneration Reactive oxygen species (ROS) NADPH oxidase (Nox) Dual oxidase (Duox) Inflammation Gryllus bimaculatus
Published Date	2025-11-15
Publication Title	Development
Volume	volume152
Issue	issue22
Publisher	The Company of Biologists
Start Page	dev204763
ISSN	0950-1991
NCID	AA10667805
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025.
File Version	publisher
PubMed ID	41263066
DOI	10.1242/dev.204763
Related Url	isVersionOf https://doi.org/10.1242/dev.204763

Role of Cytoreductive Nephrectomy in the Immune Checkpoint Inhibitor Era: A Multicenter Collaborative Study

FullText URL	fulltext.pdf
Author	Nukaya, Takuhisa\| Takahara, Kiyoshi\| Toyoda, Shingo\| Inoki, Lan\| Fukuokaya, Wataru\| Mori, Keiichiro\| Iwata, Takehiro\| Bekku, Kensuke\| Maenosono, Ryoichi\| Tsujino, Takuya\| Hirasawa, Yosuke\| Yanagisawa, Takafumi\| Hashimoto, Takeshi\| Komura, Kazumasa\| Araki, Motoo\| Fujita, Kazutoshi\| Ohno, Yoshio\| Shiroki, Ryoichi\|
Keywords	cytoreductive nephrectomy IMDC classification immune checkpoint inhibitor neutrophil-to- lymphocyte ratio sarcomatoid differentiation
Published Date	2025-08-19
Publication Title	International Journal of Urology
Volume	volume32
Issue	issue11
Publisher	Wiley
Start Page	1677
End Page	1685
ISSN	0919-8172
NCID	AA11042471
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Author(s).
File Version	publisher
PubMed ID	40831087
DOI	10.1111/iju.70207
Web of Science KeyUT	001610691000032
Related Url	isVersionOf https://doi.org/10.1111/iju.70207

iTRAQ-based quantitative proteomics reveals reduced expression of KRT19, KRT7, and PTGDS in cutaneous specimens after kidney transplantation

FullText URL	fulltext.pdf
Author	Tsuboi, Ichiro\| Mitsui, Yosuke\| Yoshinaga, Kasumi\| Yamanoi, Tomoaki\| Sekito, Takanori\| Maruyama, Yuki\| Sadahira, Takuya\| Nishimura, Shingo\| Bekku, Kensuke\| Araki, Motoo\|
Keywords	Cutaneous manifestations Keratin Skin color Pigmentation Prostaglandin D2 synthase Renal transplantation Dialysis
Published Date	2025-09-26
Publication Title	Scientific Reports
Volume	volume15
Issue	issue1
Publisher	Springer Science and Business Media LLC
Start Page	33014
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025, corrected publication 2025
File Version	publisher
PubMed ID	41006769
DOI	10.1038/s41598-025-18391-2
Web of Science KeyUT	001582556200017
Related Url	isVersionOf https://doi.org/10.1038/s41598-025-18391-2

Potential of Kidney Exchange Programs (KEPs) in Japan for Donor-Specific Antibody-Positive Kidney Transplants: A Questionnaire Survey on KEPs and a Multi-Institutional Study Conducting Virtual Cross-Matching Simulations

FullText URL	fulltext.pdf
Author	Ito, Taihei\| Ito, Miki\| Aida, Naohiro\| Kurihara, Kei\| Terao, Akihiro\| Watarai, Yoshihiko\| Saito, Mitsuru\| Kaku, Keizo\| Ishii, Daisuke\| Sekiguchi, Satoshi\| Yoneda, Tatsuo\| Unagami, Kohei\| Tasaki, Masayuki\| Iwamoto, Hitoshi\| Araki, Motoo\| Takahashi, Kazuhiro\| Yamanaka, Kazuaki\| Sugimoto, Mikio\| Nishikawa, Kouhei\| Seto, Chikashi\| Muramatsu, Masaki\| Asai, Toshihiro\| Iwami, Daiki\| Yamada, Yasutoshi\| Yamanaga, Shigeyoshi\| Komatsu, Tomonori\| Miura, Masayoshi\| Nohara, Takahiro\| Maruyama, Michihiro\| Miyauchi, Yuki\| Tanaka, Toshiaki\| Nakamura, Michio\| Hotta, Kiyohiko\| Kenmochi, Takashi\|
Keywords	kidney transplantation donor-specific antibodies kidney exchange program virtual cross-matching
Published Date	2025-08-29
Publication Title	Journal of Clinical Medicine
Volume	volume14
Issue	issue17
Publisher	MDPI AG
Start Page	6122
ISSN	2077-0383
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by the authors.
File Version	publisher
PubMed ID	40943882
DOI	10.3390/jcm14176122
Web of Science KeyUT	001569844000001
Related Url	isVersionOf https://doi.org/10.3390/jcm14176122

Rectal Swab–based Targeted Prophylactic Antibiotics Reduce Infectious Complications After Transrectal Prostate Biopsy: A Systematic Review and Meta-analysis of Randomized Controlled Trials

FullText URL	fulltext.pdf suppl.docx
Author	Tsuboi, Ichiro\| Kardoust Parizi, Mehdi\| Matsukawa, Akihiro\| Miszczyk, Marcin\| Fazekas, Tamás\| Cormio, Angelo\| Kawada, Tatsushi\| Katayama, Satoshi\| Iwata, Takehiro\| Bekku, Kensuke\| Wada, Koichiro\| Karakiewicz, Pierre I.\| Chlosta, Piotr\| Briganti, Alberto\| Araki, Motoo\| Shariat, Shahrokh F.\|
Keywords	Febrile urinary tract infection Targeted prophylactic antibiotics Transrectal prostate biopsy Sepsis
Published Date	2025-10
Publication Title	European Urology Open Science
Volume	volume80
Publisher	Elsevier BV
Start Page	57
End Page	65
ISSN	2666-1683
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Author(s).
File Version	publisher
PubMed ID	41064532
DOI	10.1016/j.euros.2025.08.007
Web of Science KeyUT	001572715700001
Related Url	isVersionOf https://doi.org/10.1016/j.euros.2025.08.007

The safety and efficacy of finasteride for transgender men with androgenetic alopecia: a case series

FullText URL	fulltext.pdf suppl1.tif suppl2.tif suppl3.tif
Author	Tominaga, Yusuke\| Kobayashi, Tomoko\| Matsumoto, Yuko\| Sako, Tomoko\| Moriwake, Takatoshi\| Horii, Satoshi\| Sadahira, Takuya\| Katayama, Satoshi\| Iwata, Takehiro\| Nishimura, Shingo\| Bekku, Kensuke\| Edamura, Kohei\| Watanabe, Masami\| Araki, Motoo\|
Keywords	Finasteride Dihydrotestosterone Transgender men Androgenetic alopecia Resumption of menstruation
Published Date	2025-09-29
Publication Title	Journal of Medical Case Reports
Volume	volume19
Issue	issue1
Publisher	Springer Science and Business Media LLC
Start Page	468
ISSN	1752-1947
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025.
File Version	publisher
PubMed ID	41024043
DOI	10.1186/s13256-025-05562-y
Web of Science KeyUT	001585008600008
Related Url	isVersionOf https://doi.org/10.1186/s13256-025-05562-y

Risk Factors for Perioperative Urinary Tract Infection After Living Donor Kidney Transplantation Characterized by High Prevalence of Desensitization Therapy: A Single-Center Analysis

FullText URL	fulltext.pdf suppl.pdf
Author	Nishimura, Shingo\| Inoue, Shota\| Sekito, Takanori\| Tsuboi, Ichiro\| Tokunaga, Moto\| Yoshinaga, Kasumi\| Maruyama, Yuki\| Mitsui, Yosuke\| Yamanoi, Tomoaki\| Kawada, Tatsushi\| Kubota, Risa\| Sadahira, Takuya\| Tominaga, Yusuke\| Iwata, Takehiro\| Katayama, Satoshi\| Bekku, Kensuke\| Edamura, Kohei\| Wada, Koichiro\| Kobayashi, Yasuyuki\| Araki, Motoo\|
Keywords	living donor kidney transplantation urinary tract infection perioperative desensitization rituximab plasmapheresis body mass index dialysis duration warm ischemic time prophylactic antimicrobials
Published Date	2025-08-28
Publication Title	Journal of Clinical Medicine
Volume	volume14
Issue	issue17
Publisher	MDPI AG
Start Page	6102
ISSN	2077-0383
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by the authors.
File Version	publisher
PubMed ID	40943861
DOI	10.3390/jcm14176102
Web of Science KeyUT	001571365300001
Related Url	isVersionOf https://doi.org/10.3390/jcm14176102

Risk of malignant neoplasms of tacrolimus in kidney transplant patients: a retrospective cohort study conducted using the Japanese National Database of Health Insurance Claims

FullText URL	fulltext.pdf suppl.docx
Author	Kubota, Risa\| Sada, Ken-Ei\| Tokunaga, Moto\| Yoshinaga, Kasumi\| Yamanoi, Tomoaki\| Kawada, Tatsushi\| Tominaga, Yusuke\| Sadahira, Takuya\| Katayama, Satoshi\| Iwata, Takehiro\| Nishimura, Shingo\| Bekku, Kensuke\| Edamura, Kohei\| Kobayashi, Tomoko\| Nakagawa, Yuki\| Ichimaru, Naotsugu\| Wada, Koichiro\| Araki, Motoo\|
Keywords	Calcineurin inhibitors Cyclosporine A Kidney transplant Malignant neoplasms Tacrolimus
Published Date	2025-08-26
Publication Title	BMC Nephrology
Volume	volume26
Issue	issue1
Publisher	Springer Science and Business Media LLC
Start Page	491
ISSN	1471-2369
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025.
File Version	publisher
PubMed ID	40859155
DOI	10.1186/s12882-025-04405-8
Web of Science KeyUT	001559427800001
Related Url	isVersionOf https://doi.org/10.1186/s12882-025-04405-8

Accuracy of Contrast-enhanced CT in Diagnosing Small-sized cT3a Renal Cell Carcinoma and Analysis of Factors Predicting Downstaging to pT1

FullText URL	fulltext.pdf
Author	BEKKU, KENSUKE\| YOSHINAGA, KASUMI\| INOUE, SHOTA\| MITSUI, YOSUKE\| YAMANOI, TOMOAKI\| KAWADA, TATSUSHI\| TOMINAGA, YUSUKE\| SADAHIRA, TAKUYA\| KATAYAMA, SATOSHI\| IWATA, TAKEHIRO\| NISHIMURA, SHINGO\| EDAMURA, KOHEI\| KOBAYASHI, TOMOKO\| ARAKI, MOTOO\|
Keywords	Contrast‑enhanced CT renal cell carcinoma staging T3a downstaging
Published Date	2025-08-28
Publication Title	In Vivo
Volume	volume39
Issue	issue5
Publisher	International Institute of Anticancer Research
Start Page	2787
End Page	2793
ISSN	0258-851X
NCID	AA10714348
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Author(s).
File Version	publisher
PubMed ID	40877189
DOI	10.21873/invivo.14077
Web of Science KeyUT	001578752300024
Related Url	isVersionOf https://doi.org/10.21873/invivo.14077

Incidence, Management, and Prevention of Gynecomastia and Breast Pain in Patients with Prostate Cancer Undergoing Antiandrogen Therapy: A Systematic Review and Meta-analysis of Randomized Controlled Trials

FullText URL	fulltext.pdf suppl.docx
Author	Tsuboi, Ichiro\| Schulz, Robert J.\| Laukhtina, Ekaterina\| Wada, Koichiro\| Karakiewicz, Pierre I.\| Araki, Motoo\| Shariat, Shahrokh F.\|
Keywords	Antiandrogen therapy Androgen deprivation therapy Androgen receptor pathway inhibitors Breast pain Gynecomastia
Published Date	2025-03
Publication Title	European Urology Open Science
Volume	volume73
Publisher	Elsevier BV
Start Page	31
End Page	42
ISSN	2666-1683
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Author(s).
File Version	publisher
PubMed ID	39935942
DOI	10.1016/j.euros.2025.01.001
Web of Science KeyUT	001422460800001
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Percutaneous cryoablation versus robot-assisted partial nephrectomy for small renal cell carcinoma: a retrospective cost analysis at Japanese single-institution

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Author	Uka, Mayu\| Iguchi, Toshihiro\| Bekku, Kensuke\| Yamanoi, Tomoaki\| Mitsuhashi, Toshiharu\| Gobara, Hideo\| Umakoshi, Noriyuki\| Kawabata, Takahiro\| Tomita, Koji\| Matsui, Yusuke\| Araki, Motoo\| Hiraki, Takao\|
Keywords	Renal cancer Cryoablation Robot-assisted partial nephrectomy Cost Cost effectiveness
Note	The version of record of this article, first published in International Journal of Clinical Oncology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10147-025-02783-5\|
Published Date	2025-06-06
Publication Title	International Journal of Clinical Oncology
Volume	volume30
Issue	issue8
Publisher	Springer Science and Business Media LLC
Start Page	1621
End Page	1630
ISSN	1341-9625
NCID	AA11086579
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	40481379
DOI	10.1007/s10147-025-02783-5
Web of Science KeyUT	001503273300001
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Eosinophils as a predictive marker of treatment-related adverse events in mRCC patients treated with first-line immune-checkpoint inhibitor combination therapy

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Author	Kawada, Tatsushi\| Katayama, Satoshi\| Yanagisawa, Takafumi\| Mori, Keiichiro\| Fukuokaya, Wataru\| Komura, Kazumasa\| Tsujino, Takuya\| Maenosono, Ryoichi\| Takahara, Kiyoshi\| Nukaya, Takuhisa\| Inoki, Lan\| Toyoda, Shingo\| Hashimoto, Takeshi\| Hirasawa, Yosuke\| Edamura, Kohei\| Kobayashi, Tomoko\| Bekku, Kensuke\| Nishimura, Shingo\| Iwata, Takehiro\| Sadahira, Takuya\| Tominaga, Yusuke\| Yamanoi, Tomoaki\| Yoshinaga, Kasumi\| Tsuboi, Kazuma\| Kobayashi, Yasuyuki\| Takamoto, Atsushi\| Kurose, Kyohei\| Kimura, Takahiro\| Azuma, Haruhito\| Shiroki, Ryoichi\| Fujita, Kazutoshi\| Ohno, Yoshio\| Araki, Motoo\|
Keywords	Renal cell carcinoma Immune checkpoint inhibitor ICI Eosinophil Immune-related adverse event Treatment-related adverse event
Published Date	2025-07-25
Publication Title	Scientific Reports
Volume	volume15
Issue	issue1
Publisher	Springer Science and Business Media LLC
Start Page	27163
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	40715213
DOI	10.1038/s41598-025-08767-9
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LAG3 regulates antibody responses in a murine model of kidney transplantation

FullText URL	fulltext.pdf suppl1.pdf suppl2.pdf suppl3.xlsx
Author	Nicosia, Michael\| Fan, Ran\| Lee, Juyeun\| All, Gabriella\| Gorbacheva, Victoria\| Valenzuela, José I.\| Yamamoto, Yosuke\| Beavers, Ashley\| Dvorina, Nina\| Baldwin, William M.\| Chuluyan, Eduardo\| Araki, Motoo\| Gaudette, Brian T.\| Fairchild, Robert L.\| Min, Booki\| Valujskikh, Anna\|
Published Date	2025-05-13
Publication Title	Journal of Clinical Investigation
Volume	volume135
Issue	issue13
Publisher	American Society for Clinical Investigation
Start Page	e172988
ISSN	1558-8238
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025, Nicosia et al.
File Version	publisher
PubMed ID	40359031
DOI	10.1172/jci172988
Web of Science KeyUT	001530480600007
Related Url	isVersionOf https://doi.org/10.1172/jci172988

Distribution of Fimbrial Genes and Their Association with Virulence and Levofloxacin Resistance/Extended-Spectrum Beta-Lactamase Production in Uropathogenic Escherichia coli

FullText URL	fulltext.pdf
Author	Mitsui, Masao\| Sekito, Takanori\| Maruhashi, Mai\| Maruyama, Yuki\| Iwata, Takehiro\| Tominaga, Yusuke\| Katayama, Satoshi\| Nishimura, Shingo\| Bekku, Kensuke\| Araki, Motoo\| Hirakawa, Hidetada\| Sadahira, Takuya\|
Keywords	fimbriae urinary tract infection drug resistance virulence uropathogenic Escherichia coli
Published Date	2025-05-06
Publication Title	Antibiotics
Volume	volume14
Issue	issue5
Publisher	MDPI AG
Start Page	468
ISSN	2079-6382
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by the authors.
File Version	publisher
PubMed ID	40426535
DOI	10.3390/antibiotics14050468
Web of Science KeyUT	001496482900001
Related Url	isVersionOf https://doi.org/10.3390/antibiotics14050468

Impact of concomitant medications on the oncologic efficacy of systemic therapy in patients with advanced or metastatic urothelial carcinoma: a systematic review and meta-analysis

FullText URL	fulltext.pdf suppl.docx
Author	Tsuboi, Ichiro\| Matsukawa, Akihiro\| Parizi, Mehdi Kardoust\| Miszczyk, Marcin\| Fazekas, Tamás\| Schulz, Robert J\| Laukhtina, Ekaterina\| Kawada, Tatsushi\| Katayama, Satoshi\| Iwata, Takehiro\| Bekku, Kensuke\| Rajwa, Pawel\| Wada, Koichiro\| Oberneder, Katharina\| Chlosta, Piotr\| Karakiewicz, Pierre I.\| Araki, Motoo\| Shariat, Shahrokh F.\|
Keywords	Concomitant medications Proton pump inhibitors Antibiotics steroids Opioids Histamine type-2 receptor antagonists Immune checkpoint inhibitors Urothelial carcinoma
Published Date	2025-04-28
Publication Title	BMC Urology
Volume	volume25
Issue	issue1
Publisher	Springer Science and Business Media LLC
Start Page	107
ISSN	1471-2490
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025.
File Version	publisher
PubMed ID	40296069
DOI	10.1186/s12894-025-01754-2
Web of Science KeyUT	001478272600002
Related Url	isVersionOf https://doi.org/10.1186/s12894-025-01754-2

Postoperative infections after robotic‐assisted radical prostatectomy in a single large institution: Effect of type and duration of prophylactic antibiotic administration

FullText URL	fulltext.pdf
Author	Mitsui, Masao\| Sadahira, Takuya\| Nagasaki, Naoya\| Maruyama, Yuki\| Sekito, Takanori\| Iwata, Takehiro\| Katayama, Satoshi\| Bekku, Kensuke\| Araki, Motoo\|
Keywords	cefazolin postoperative infections prophylactic antibiotics prostate robotic-assisted radical prostatectomy
Published Date	2024-11-18
Publication Title	International Journal of Urology
Volume	volume32
Issue	issue3
Publisher	Wiley
Start Page	258
End Page	263
ISSN	0919-8172
NCID	AA11042471
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 The Author(s).
File Version	publisher
PubMed ID	39555690
DOI	10.1111/iju.15635
Web of Science KeyUT	001358046200001
Related Url	isVersionOf https://doi.org/10.1111/iju.15635

Influence of tumor‑associated factors on the treatment selection between partial nephrectomy and ablation therapy for small renal tumors (Review)

FullText URL	fulltext.pdf
Author	Bekku, Kensuke\| Inoue, Shota\| Yoshinaga, Kasumi\| Yamanoi, Tomoaki\| Mitsui, Yosuke\| Kawada, Tatsushi\| Tominaga, Yusuke\| Sadahira, Takuya\| Iwata, Takehiro\| Katayama, Satoshi\| Nishimura, Shingo\| Edamura, Kohei\| Kobayashi, Tomoko\| Araki, Motoo\|
Keywords	small renal mass partial nephrectomy ablation therapy tumor location endophytic tumor
Published Date	2025-06-04
Publication Title	Medicine International
Volume	volume5
Issue	issue4
Publisher	Spandidos Publications
Start Page	48
ISSN	2754-3242
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© Bekku et al.
File Version	publisher
PubMed ID	40529723
DOI	10.3892/mi.2025.247
Related Url	isVersionOf https://doi.org/10.3892/mi.2025.247

Nephronophthisis and Retinitis Pigmentosa (Senior-Loken Syndrome) After Living-Donor Kidney Transplantation: Twelve-Year Follow-Up in a Young Woman

FullText URL	fulltext20250602-01.pdf
Author	Matsuo, Toshihiko\| Onishi, Yasuhiro\| Morinaga, Hiroshi\| Wada, Jun\| Tanaka, Takehiro\| Araki, Motoo\|
Keywords	Retinitis pigmentosa Nephronophthisis Senior-Loken syndrome Kidney transplantation Living donor Kidney biopsy Pathology Computed tomography scan Ciliopathy Optical coherence tomography
Published Date	2025-05
Publication Title	Journal of Medical Cases
Volume	volume16
Issue	issue5
Publisher	Elmer Press, Inc.
Start Page	164
End Page	173
ISSN	1923-4155
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The authors
File Version	publisher
PubMed ID	40503542
DOI	10.14740/jmc4356
Web of Science KeyUT	001506125600002
Related Url	isVersionOf https://doi.org/10.14740/jmc4356

泌尿器科領域におけるロボット手術の進化と未来

Title Alternative	The advances in robot-assisted surgery in the field of urology and future perspective
Author	Bekku, Kensuke\| Nagasaki, Naoya\| Okamoto, Yusuke\| Shiraishi, Hiromasa\| Taira, Aya\| Inoue, Shota\| Kawago, Yuya\| Watanabe, Tomofumi\| Mitsui, Masao\| Horii, Satoshi\| Moriwake, Takatoshi\| Yoshinaga, Kasumi\| Mitsui, Yosuke\| Yamanoi, Tomoaki\| Kawada, Tatsushi\| Sadahira, Takuya\| Tominaga, Yusuke\| Iwata, Takehiro\| Katayama, Satoshi\| Nishimura, Shingo\| Edamura, Kohei\| Kobayashi, Tomoko\| Araki, Motoo\|
Keywords	ロボット手術ダビンチ泌尿器科領域
Publication Title	Journal of Okayama Medical Association
Published Date	2025-04-01
Volume	volume137
Issue	issue1
Start Page	25
End Page	29
ISSN	0030-1558
Related Url	isVersionOf https://doi.org/10.4044/joma.137.25
language	Japanese
Copyright Holders	Copyright (c) 2025 岡山医学会
File Version	publisher
DOI	10.4044/joma.137.25

Clinical Outcomes of Neoadjuvant Paclitaxel/Cisplatin/Gemcitabine Compared with Gemcitabine/Cisplatin for Muscle-Invasive Bladder Cancer

JaLCDOI	10.18926/AMO/68646
FullText URL	79_2_081.pdf
Author	Kawada, Tatsushi\| Kobayashi, Yasuyuki\| Tsugawa, Takuji\| Tsuboi, Kazuma\| Katayama, Satoshi\| Iwata, Takehiro\| Bekku, Kensuke\| Kobayashi, Tomoko\| Edamura, Kohei\| Ebara, Shin\| Araki, Motoo\|
Abstract	We retrospectively evaluated the oncologic outcomes of paclitaxel, cisplatin, and gemcitabine (PCG) with those of gemcitabine and cisplatin (GC) as neoadjuvant chemotherapy in muscle-invasive bladder cancer (MIBC) patients. The primary outcome was efficacy: pathological complete response (pCR), ypT0N0; and pathological objective response (pOR), ypT0N0, ≤ ypT1N0, or ypT0N1. Secondary outcomes included overall survival (OS), recurrence-free survival (RFS), predictive factors for pOR, OS, and RFS, and hematologic adverse events (AEs). Among 113 patients treated (PCG, n=28; GC, n=85), similar pOR and pCR rates were achieved by the groups (pOR: PCG, 57.1% vs. GC, 49. 4%; p=0.52; pCR: PCG, 39.3% vs. GC, 29.4%; p=0.36). No significant differences were observed in OS (p=1.0) or RFS (p=0.20). Multivariate logistic regression analysis showed that hydronephrosis (odds ratio [OR] 0.32, 95%CI: 0.11-0.92) and clinical node-positive status (cN+) (OR 0.22, 95%CI: 0.050-0.99) were significantly associated with a decreased probability of pOR. On multivariate Cox regression analyses, pOR achievement was associated with improved OS (hazard ratio [HR] 0.23, 95%CI: 0.10-0.56) and RFS (HR 0.30, 95%CI: 0.13-0.67). There were no significant between-group differences in the incidence of grade ≥ 3 hematologic AEs or dose-reduction required, but the PCG group had a higher incidence of grade 4 neutropenia.
Keywords	urothelial carcinoma paclitaxel cisplatin gemcitabine neoadjuvant
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2025-04
Volume	volume79
Issue	issue2
Publisher	Okayama University Medical School
Start Page	81
End Page	92
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2025 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	40302279
Web of Science KeyUT	001485544200003