ID | 54507 |
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Araki, Motoo
Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Wada, Koichiro
Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Mitsui, Yosuke
Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kubota, Risa
Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Yoshioka, Takashi
Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Ariyoshi, Yuichi
Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kobayashi, Yasuyuki
Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Kitagawa, Masashi
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Tanabe, Katsuyuki
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Sugiyama, Hiroshi
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Wada, Jun
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Watanabe, Masami
Center for Innovative Clinical Medicine, Okayama University Hospital
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Watanabe, Toyohiko
Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Hotta, Katsuyuki
Center for Innovative Clinical Medicine, Okayama University Hospital
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Nasu, Yasutomo
Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Abstract | Although graft survival following renal transplantation (RTx) has improved, outcomes following highrisk RTx are variable. Preexisting antibodies, including donor-specific antibodies (DSA), play an important role in graft dysfunction and survival. We have designed a study to investigate the safety and efficacy of anti-CD20 monoclonal antibodies (rituximab) in high-risk RTx recipients. Major eligibility criteria include: 1) major and minor ABO blood group mismatch, 2) positive DSA. Thirty-five patients will receive 200 mg/body of rituximab. The primary endpoint is the incidence of B cell depletion. This study will clarify whether rituximab is efficacious in improving graft survival in high-risk RTx recipients.
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Keywords | end-stage renal disease
immunosuppression
kidney transplantation
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Amo Type | Clinical Study Protocols
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Publication Title |
Acta Medica Okayama
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Published Date | 2016-08
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Volume | volume70
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Issue | issue4
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Publisher | Okayama University Medical School
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Start Page | 295
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End Page | 297
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School
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File Version | publisher
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Refereed |
True
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Web of Science KeyUT |