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ID 11425
Eprint ID
11425
FullText URL
Title Alternative
A mathematical model of Plasmodium falciparum transmission incorporating drug resistance: Simulations of the Solomon Islands situation
Author
Chen, Tiantian
Nishina, Tomohiko
Hisakane, Naoto
Abstract
The Solomon Islands are known as a high endemic region of malaria. The resistance of Plasmodium falciparum to chloroquine has been confirmed since 1980 in the Solomon Islands, and the spread of chloroquine resistance is a big hurdle to malaria control. We have constructured the model for P. falciparum making allowance of chloroquine resistance. We distinguish the infection of resistance strains from that of sensitive strains in both the human and the vector populations. Since the overall parasite rate and the parasite rate of gametocytes for P. falciparum are strongly dependent on age, the human population is divided into 7 age groups in the model. The epidemiological parameters are determined by malariological survey in northeastern Guadalcanal (Ishii et al.) and the sporozoite rate in vector population is assumed as 0.1% based on the entomological study (Harada et al.) Our study aims at estimating the effect of mass drug administration under the presence of drug-resistance and also analyzing the escalation of drug-resistance through the transmission model for P. falciparum which can deal with chloroquine resistance.
Keywords
Solomon Islands
Plasmodium falciparum
drug resistance
model
Published Date
2007-03-15
Publication Title
岡山大学環境理工学部研究報告
Publication Title Alternative
Journal of the Faculty of Environmental Science and Technology, Okayama University
Volume
volume12
Issue
issue1
Publisher
岡山大学環境理工学部
Publisher Alternative
Faculty of Environmental Science and Technology, Okayama University
Start Page
19
End Page
27
ISSN
1341-9099
NCID
AN10529213
Content Type
Departmental Bulletin Paper
Related Url
http://www.okayama-u.ac.jp/user/est/homeJapan.html
language
日本語
File Version
publisher
Refereed
False
Eprints Journal Name
fest