ID | 52799 |
FullText URL | |
Author |
Komatsu, Seiji
Nagai, Yusuke
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Abstract | Conventional self-assembling peptide hydrogels are effective as topical hemostatic agents. However, there is a possibility to harm living tissues due to their low pH. The aim of the present study was to demonstrate the efficacy of SPG-178, a neutral self-assembling peptide hydrogel, as a topical hemostatic agent. First, we measured the bleeding duration of incisions made on rat livers after application of SPG-178 (1.0% w/v), SPG-178 (1.5% w/v), RADA16 (1.0% w/v), and saline (n = 12/group). Second, we observed the bleeding surfaces by transmission electron microscopy immediately after hemostasis. Third, we measured the elastic and viscous responses (G′ and G″, respectively) of the hydrogels using a rheometer. Our results showed that bleeding duration was significantly shorter in the SPG-178 group than in the RADA16 group and that there were no significant differences in transmission electron microscopy findings between the groups. The greater the G′ value of a hydrogel, the shorter was the bleeding duration. We concluded that SPG-178 is more effective and has several advantages: it is non-biological, transparent, nonadherent, and neutral and can be sterilized by autoclaving.
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Published Date | 2014-07-21
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Publication Title |
PLoS ONE
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Volume | volume9
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Issue | issue7
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Publisher | Public Library Science
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ISSN | 1932-6203
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Content Type |
Journal Article
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language |
English
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Copyright Holders | © 2014 Komatsu et al.
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File Version | publisher
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Refereed |
True
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DOI |