Study about the Efficacy of Metformin to Immune Function in Cancer Patients

Watanabe, Mototsugu; Yamamoto, Hiromasa; Eikawa, Shingo; Shien, Kazuhiko; Shien, Tadahiko; Soh, Junichi; Hotta, Katsuyuki; Wada, Jun; Hinotsu, Shiro; Fujiwara, Toshiyoshi; Kiura, Katsuyuki; Doihara, Hiroyoshi; Miyoshi, Shinichiro; Udono, Heiichiro; Toyooka, Shinichi

ID	54514
JaLCDOI	10.18926/AMO/54514
FullText URL	70_4_327.pdf 1.83 MB
Author	Watanabe, Mototsugu Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Yamamoto, Hiromasa Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap Eikawa, Shingo Department of Immunology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID Shien, Kazuhiko Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap Shien, Tadahiko Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap Soh, Junichi Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID researchmap Hotta, Katsuyuki Center for Innovative Clinical Medicine, Okayama University Hospital Kaken ID publons researchmap Wada, Jun Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap Hinotsu, Shiro Center for Innovative Clinical Medicine, Okayama University Hospital Kaken ID researchmap Fujiwara, Toshiyoshi Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap Kiura, Katsuyuki Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap Doihara, Hiroyoshi Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID researchmap Miyoshi, Shinichiro Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID publons researchmap Udono, Heiichiro Department of Immunology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID researchmap Toyooka, Shinichi Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap
Abstract	A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8＋ T cells, which produce multiple cytokines.
Keywords	metformin CD8＋ T cells cancer immunology
Amo Type	Clinical Study Protocols
Publication Title	Acta Medica Okayama
Published Date	2016-08
Volume	volume70
Issue	issue4
Publisher	Okayama University Medical School
Start Page	327
End Page	330
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2016 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	27549683
Web of Science KeyUT	000384748600018