FullText URL K0005440_other1.pdf
Author Hiroshi, Umemura| Yamasaki, Osamu| Kaji, Tatsuya| Otsuka, Masaki| Asagoe, Kenji| Takata, Minoru| Iwatsuki, Keiji|
Keywords 5-S-cysteinyl-dopa biomarker lactate dehydrogenase malignant melanoma serum 5-S-CD
Note 学位審査副論文
Published Date 2017-04
Publication Title Journal of Dermatology
Volume volume44
Issue issue4
Publisher Wiley-Blackwell
Start Page 449
End Page 454
ISSN 03852407
NCID AA00696658
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 27786364
DOI 10.1111/1346-8138.13651
Web of Sience KeyUT 000398690600029
Related Url isVersionOf https://doi.org/10.1111/1346-8138.13651
Title Alternative The 40th Annual Meeting of the Japanese Society for Investigative Dermatology
FullText URL 128_71.pdf
Author Iwatsuki, Keiji|
Publication Title 岡山医学会雑誌
Published Date 2016-04-01
Volume volume128
Issue issue1
Start Page 71
End Page 72
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.128.71
language 日本語
Copyright Holders Copyright (c) 2016 岡山医学会
File Version publisher
DOI 10.4044/joma.128.71
NAID 130005149606
Author Tada, Kotaro| Hamada, Toshihisa| Asagoe, Kenji| Umemura, Hiroshi| Mizuno-Ikeda, Kazuko| Aoyama, Yumi| Otsuka, Masaki| Yamasaki, Osamu| Iwatsuki, Keiji|
Published Date 2014-11
Publication Title European Journal of Dermatology
Volume volume24
Issue issue6
Content Type Journal Article
JaLCDOI 10.18926/AMO/53118
FullText URL 69_1_17.pdf
Author Suzuki, Norihiro| Takata, Minoru| Shirafuji, Yoshinori| Otsuka, Masaki| Yamasaki, Osamu| Asagoe, Kenji| Hatta, Naohito| Iwatsuki, Keiji|
Abstract Sentinel lymph node (SLN) biopsies have widely been used for the detection of occult LN metastasis of malignant melanoma (MM). In addition to conventional biomarkers, we assessed the diagnostic and prognostic significance of melanoma-initiating cell (MIC) markers in SLNs of MM. We examined the expressions of gp100, MART-1 and tyrosinase mRNA for routine diagnosis and those of ABCB5, CD133, nestin, KDM5B, NGFR and RANK mRNA as MIC markers. The presence of micrometastasis was confirmed immunohistochemically using antibodies to S-100, HMB-45, MART-1, and tyrosinase. Discordance between immunohistochemical and molecular data was observed in 14 of 70 (20.0%) patients, among whom five (7.1%) were positive for only molecular markers;two of these five patients tested positive for micrometastasis by repeated immunohistochemical stainings. The quantitative expression levels of gp100, MART-1, and tyrosinase mRNA were significantly higher in the metastatic LNs;the cut-off values remain to be elucidated. ABCB5 mRNA expression was detected more frequently in the metastatic SLNs (p<0.05) and in the group of patients with recurrence. To make a definite diagnosis of metastasis, we still need a combination of immunohistochemical and molecular probes. ABCB5 might be a suitable molecular marker for the detection of melanoma-initiating cells in SLNs.
Keywords melanoma cancer-initiating cell sentinel lymph node ABCB5
Amo Type Original Article
Published Date 2015-02
Publication Title Acta Medica Okayama
Volume volume69
Issue issue1
Publisher Okayama University Medical School
Start Page 17
End Page 27
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25703167
Web of Sience KeyUT 000349740300002
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/53114
FullText URL Bri_Jou_Der_171_3_492-498.pdf
Author Takiguchi, T| Morizane, S| Yamamoto, T| Kajita, A| Ikeda, K| Iwatsuki, K|
Note This is the accepted version of the following article: FULLCITE, which has been published in final form at http://dx.doi.org/10.1111/bjd.12942| 学位審査副論文|
Published Date 2014-09
Publication Title British Journal of Dermatology
Volume volume171
Issue issue3
Start Page 492
End Page 498
ISSN 0007-0963
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2014 British Association of Dermatologists
File Version author
PubMed ID 24601852
DOI 10.1111/bjd.12942
Web of Sience KeyUT 000344006900186
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/52974 http://ousar.lib.okayama-u.ac.jp/53764
Title Alternative The 113th Annual Meeting of the Japanese Dermatological Association
FullText URL 126_255.pdf
Author Iwatsuki, Keiji|
Publication Title 岡山医学会雑誌
Published Date 2014-12-01
Volume volume126
Issue issue3
Start Page 255
End Page 257
ISSN 0030-1558
language 日本語
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
DOI 10.4044/joma.126.255
NAID 130004903249
Author Hamada, Toshihisa| Iwatsuki, Keiji|
Published Date 2014-01
Publication Title The Journal of Dermatology
Volume volume41
Issue issue1
Content Type Journal Article
Title Alternative SFTS : Severe fever with thrombocytopenia syndrome
FullText URL 126_65.pdf
Author Watanabe, Tokiko| Kusano, Nobuchika| Iwatsuki, Keiji|
Publication Title 岡山医学会雑誌
Published Date 2014-04-01
Volume volume126
Issue issue1
Start Page 65
End Page 67
ISSN 0030-1558
Related Url http://www.okayama-u.ac.jp/user/oma/
language 日本語
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
DOI 10.4044/joma.126.65
Author Morizane, Shin| Yamasaki, Kenshi| Kajita, Ai| Ikeda, Kazuko| Zhan, Maosheng| Aoyama, Yumi| Richard L Gallo| Iwatsuki, Keiji|
Published Date 2013-12-02
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue3
Content Type Journal Article
Author Kamiya, K| Aoyama, Y| Shirafuji, Y| Hamada, T| Morizane, S| Fujii, K| Hisata, K| Iwatsuki, K|
Published Date 2012-08
Publication Title British Journal of Dermatology
Volume volume167
Issue issue2
Content Type Journal Article
Author Iwatsuki, Keiji|
Published Date 2010-08-02
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue2
Content Type Journal Article
Author Iwatsuki, Keiji|
Published Date 2010-08-02
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue2
Content Type Journal Article
JaLCDOI 10.18926/AMO/32089
FullText URL fulltext.pdf
Author Iwatsuki, Keiji| Yamamoto, Takenobu| Tsuji, Kazuhide| Suzuki, Daisuke| Fujii, Kazuyasu| Matsuura, Hironori| Oono, Takashi|
Abstract <p>Epstein-Barr virus (EBV), or human herpesvirus 4 (HHV-4), infects the vast majority of adults worldwide, and establishes both nonproductive (latent) and productive (lytic) infections. Host immune responses directed against both the lytic and latent cycle-associated EBV antigens induce a diversity of clinical symptoms in patients with chronic active EBV infections who usually contain an oligoclonal pool of EBV-infected lymphocyte subsets in their blood. Episomal EBV genes in the latent infection utilize an array of evasion strategies from host immune responses: the minimized expression of EBV antigens targeted by host cytotoxic T lymphocytes (CTLs), the down-regulation of cell adhesion molecule expression, and the release of virokines to inhibit the host CTLs. The oncogenic role of latent EBV infection is not yet fully understood, but latent membrane proteins (LMPs) expressed during the latency cycle have essential biological properties leading to cellular gene expression and immortalization, and EBV-encoded gene products such as viral interleukin-10 (vIL-10) and bcl-2 homologue function to survive the EBV-infected cells. The subsequent oncogenic DNA damage may lead to the development of neoplasms. EBV-associated NK/T cell lymphoproliferative disorders are prevalent in Asia, but quite rare in Western countries. The genetic immunological background, therefore, is closely linked to the development of EBV-associated neoplasms.</p>
Keywords latent infection hydroa vacciniforme mosquito allergy chronic active EB virus infection hemophagocytic syndrome
Amo Type Article
Published Date 2004-08
Publication Title Acta Medica Okayama
Volume volume58
Issue issue4
Publisher Okayama University Medical School
Start Page 169
End Page 180
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 15551754
Web of Sience KeyUT 000223559700001
Author 秋山 尚範| 荒田 次郎| 岩月 啓氏|
Published Date 2001-04-28
Publication Title 岡山医学会雑誌
Volume volume113
Issue issue1
Content Type Journal Article
Author Otsuka, Masaki| Asagoe, Kenji| Iwatsuki, Keiji|
Published Date 2008-08-01
Publication Title 岡山医学会雑誌
Volume volume120
Issue issue2
Content Type Journal Article