ID | 54912 |
Sort Key | 5
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Title Alternative | Changes of colonic mucosa caused by long-term use and discontinuation of anthraquinone
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Author |
Iwano, Eiji
Kamogata Clinic
Iwamuro, Masaya
Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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岡田 裕之
Departments of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
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Abstract | Anthraquinone, an anthracene derivatives, is widely used as a purgative medicine. The long-term use of anthraquinone is known to cause melanosis coli and elevated lesions in the colon. However, the clinical course of patients who take anthraquinone over a long term and those who discontinue the drug has not been fully investigated. Here we investigated 22 patients who had colonic mucosal changes ( i.e., melanosis coli and elevated lesions) who had been taking anthraquinone for at least one year and discontinued it. We classified the elevated lesions into two subtypes:the small-lesion, which included multiple small nodules that were < 2 mm in dia., and the large-lesion, which included a single or multiple nodules of ≥ 2-mm dia. We used colonoscopy to investigate the changes of colonic lesions between before and after the discontinuation of anthraquinone. The results indicated that the nodules of the small-lesion group were lymphoid follicle hyperplasia. In the large-lesion group, adenoma was most frequently observed ( n=118) , followed by hyperplastic polyp ( n=52) and inflammatory changes with edema ( n=22) . Melanosis coli and elevated lesions were decreased or invisible after the discontinuation of anthraquinone. Our findings thus suggest that the long-term use of anthraquinone may cause some type of elevated lesions due to chronic inflammation. It is recommended that the use of anthraquinone be limited to a short term.
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Keywords | アントラセン誘導体(anthracene derivatives)
アントラキノン(anthraquinone)
大腸黒皮症(melanosis coli)
大腸メラノーシス(pseudomelanosis coli)
リンパ濾胞過形成(lymphoid follicle hyperplasia)
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Note | 原著(Originals)
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Publication Title |
Journal of Okayama Medical Association
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Published Date | 2017-04-03
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Volume | volume129
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Issue | issue1
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Publisher | 岡山医学会
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Publisher Alternative | Okayama Medical Association
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Start Page | 23
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End Page | 30
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ISSN | 0030-1558
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NCID | AN00032489
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Content Type |
Journal Article
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OAI-PMH Set |
岡山大学
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language |
Japanese
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Copyright Holders | Copyright (c) 2017 岡山医学会
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File Version | publisher
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Refereed |
True
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DOI | |
NAID | |
Eprints Journal Name | joma
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