ID | 53635 |
FullText URL | |
Author |
Ebinuma, Takayuki
Sato, Takamaro
Matsunaga, Kazuyuki
Kudo, Chieko
Maeda, Hiroshi
Maeda, Yoshinobu
Kaken ID
researchmap
|
Abstract | [Purpose]
We recently reported frequent detection of antibiotic-resistant bacteria on the oral mucosa during the period of hematopoietic cell transplantation (HCT) and suggested an association between oral mucositis and antibiotic-resistant bacterial infection. Methicillin-resistant Staphylococcus spp. were frequently detected, and the oral cavity may be a reservoir of the gene mediating methicillin resistance, mecA. Here, we examined the frequency of mecA carriers in patients undergoing HCT.
[Methods]
Fifty-nine patients (male (M) = 37, female (F) = 22, 47.3 ± 11.0 years) receiving HCT were enrolled in this study. Buccal swab samples were obtained four times from day −7 to day +20 (once/week), and mecA was detected by PCR. Fifty-two subjects without systemic disease, who completed dental treatment, especially periodontal treatment (M = 21, F = 31, 55.4 ± 14.2 years), were also enrolled as controls and checked for mecA on the oral mucosa.
[Results]
Seventy-six percent (45/59) of the HCT patients carried mecA at least once in the study period (days −7 to +20), while no control subjects had mecA. The frequency of mecA carriers was 19.2 % from days −7 to −1, while it was significantly increased on days +7 to +13 and +14 to +20, with frequencies of 60.9 and 63.2 %, respectively (P < 0.01, ANOVA).
[Conclusions]
mecA was detected in oral mucosa of patients undergoing HCT. The high detection frequency of staphylococci resistant to penicillin and beta-lactams in our recent report was supported.
|
Keywords | Hematopoietic cell transplantation
Oral mucosa
Bacteria
mecA
Antibiotic-resistant
|
Note | The final publication is available at Springer via http://dx.doi.org/10.1007/s00520-014-2151-1
|
Published Date | 2014-06
|
Publication Title |
Supportive Care in Cancer
|
Volume | volume22
|
Issue | issue6
|
Publisher | Springer Berlin Heidelberg
|
Start Page | 1679
|
End Page | 1683
|
ISSN | 0941-4355
|
NCID | AA10996793
|
Content Type |
Journal Article
|
Official Url | http://link.springer.com/journal/520
|
language |
English
|
Copyright Holders | Springer-Verlag Berlin Heidelberg
|
File Version | author
|
Refereed |
True
|
DOI | |
PubMed ID | |
Web of Science KeyUT |