| ID | 57797 |
| FullText URL | |
| Author |
Yoshioka, Yohsuke
Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Yamachika, Eiki
Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Hospital
Nakanishi, Makoto
Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
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Ninomiya, Tadashi
Department of Anatomy, Nihon University School of Dentistry
Akashi, Sho
Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kondo, Sei
Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Moritani, Norifumi
Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Kobayashi, Yasuhiro
Division of Hard Tissue Research, Institute for Oral Science, Matsumoto Dental University
Fujii, Tatsuo
Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
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Iida, Seiji
Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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| Abstract | Intermittent parathyroid hormone (PTH) administration is known to promote bone healing after surgical procedures. However, the mechanism and influence of PTH on the mineral and collagen quality of the jaw are not well understood. Most studies have focused on analyzing the bone density and microstructure of the mandible, and have insufficiently investigated its mineral and collagen quality. Oxidative stress activates osteoclasts, produces advanced glycation end products, and worsens mineral and collagen quality. We hypothesized that PTH induces oxidation and affects the mineral and collagen quality of newly formed mandibular bone. To test this, we examined the mineral and collagen quality of newly formed mandibular bone in rats administered PTH, and analyzed serum after intermittent PTH administration to examine the degree of oxidation. PTH administration reduced mineralization and worsened mineral and collagen quality in newly formed bone. In addition, total anti-oxidant capacity in serum was significantly decreased and the oxidative-INDEX was increased among PTH-treated compared to vehicle-treated rats, indicating serum oxidation. In conclusion, intermittent administration of PTH reduced mineral and collagen quality in newly formed mandibular bone. This effect may have been induced by oxidation.
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| Published Date | 2019-5-29
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| Publication Title |
Scientific Reports
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| Volume | volume9
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| Publisher | Nature Publishing Group
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| Start Page | 8041
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| ISSN | 2045-2322
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| Content Type |
Journal Article
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| language |
English
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| OAI-PMH Set |
岡山大学
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| Copyright Holders | © The Author(s) 2019
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| File Version | publisher
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| PubMed ID | |
| DOI | |
| Web of Science KeyUT | |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-019-44389-8
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| License | https://creativecommons.org/licenses/by/4.0/
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| Funder Name |
Japan Society for the Promotion of Science
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| 助成番号 | JP18K09721
JP18H06309
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