ID | 61351 |
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Author |
Soe, Tet Htut
Department of Biotechnology, Mandalay Technological University
Watanabe, Kazunori
Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University
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Ohtsuki, Takashi
Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University
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Abstract | Endosomal escape in cell-penetrating peptide (CPP)-based drug/macromolecule delivery systems is frequently insufficient. The CPP-fused molecules tend to remain trapped inside endosomes and end up being degraded rather than delivered into the cytosol. One of the methods for endosomal escape of CPP-fused molecules is photochemical internalization (PCI), which is based on the use of light and a photosensitizer and relies on photoinduced endosomal membrane destabilization to release the cargo molecule. Currently, it remains unclear how this delivery strategy behaves after photostimulation. Recent findings, including our studies using CPP-cargo-photosensitizer conjugates, have shed light on the photoinduced endosomal escape mechanism. In this review, we discuss the structural design of CPP-photosensitizer and CPP-cargo-photosensitizer conjugates, and the PCI mechanism underlying their application.
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Keywords | photochemical internalization
photosensitizer
cell-penetrating peptide
endosome
membrane
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Published Date | 2020-12-23
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Publication Title |
Molecules
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Volume | volume26
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Issue | issue1
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Publisher | MDPI
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Start Page | 36
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ISSN | 1420-3049
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © 2020 by the authors.
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File Version | publisher
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Related Url | isVersionOf https://doi.org/10.3390/molecules26010036
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License | https://creativecommons.org/licenses/by/4.0/
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Funder Name |
Japan Society for the Promotion of Science
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助成番号 | JP18H02090
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