Yoshimura, Teizo - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

SPRED2 controls the severity of cisplatin-induced acute kidney injury by inhibiting ERK activation and TNFα production in mice

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Author	Yang, Xu\| He, Jiali\| Gao, Tong\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Kunkel, Steven L.\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	Cisplatin ERK Macrophage SPRED2 TNFα
Published Date	2026-02
Publication Title	Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Volume	volume1873
Issue	issue2
Publisher	Elsevier BV
Start Page	120091
ISSN	0167-4889
NCID	AA1050609X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Authors.
File Version	publisher
PubMed ID	41330472
DOI	10.1016/j.bbamcr.2025.120091
Related Url	isVersionOf https://doi.org/10.1016/j.bbamcr.2025.120091

Neurofibromin Encoded by the Neurofibromatosis Type 1 (NF1) Gene Promotes the Membrane Translocation of SPRED2, Thereby Inhibiting the ERK Pathway in Breast Cancer Cells

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Author	Su Pwint, Nang Thee\| Li, Chunning\| Gao, Tong\| Wang, Yuze\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Sakaguchi, Masakiyo\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	breast cancer SPRED2 neurofibromatosis type 1 neurofibromin RAS/RAF/ERK
Published Date	2025-10-16
Publication Title	International Journal of Molecular Sciences
Volume	volume26
Issue	issue20
Publisher	MDPI AG
Start Page	10072
ISSN	1422-0067
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by the authors.
File Version	publisher
DOI	10.3390/ijms262010072
Related Url	isVersionOf https://doi.org/10.3390/ijms262010072

Pseudohypoxia induced by iron chelator activates tumor immune response in lung cancer

Author	Hamada, Yusuke\| Ohara, Toshiaki\| Chen, Yuehua\| Terada, Manato\| Wang, Yuze\| Kawai, Hotaka\| Fujisawa, Masayoshi\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	Lung cancer iron hypoxia-inducible factor immune checkpoint inhibitors
Note	This is an Accepted Manuscript of an article published by Taylor & Francis in Free Radical Research on 30 Aug 2025, available at: https://doi.org/10.1080/10715762.2025.2551030.\| This fulltext file will be available in Aug. 2026.\|
Published Date	2025-08-30
Publication Title	Free Radical Research
Publisher	Informa UK Limited
ISSN	1071-5762
NCID	AA11001805
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	40850320
DOI	10.1080/10715762.2025.2551030
Web of Science KeyUT	001560636600001
Related Url	isVersionOf https://doi.org/10.1080/10715762.2025.2551030

HIF-PH inhibitors induce pseudohypoxia in T cells and suppress the growth of microsatellite stable colorectal cancer by enhancing antitumor immune responses

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Author	Chen, Yuehua\| Ohara, Toshiaki\| Hamada, Yusuke\| Wang, Yuze\| Tian, Miao\| Noma, Kazuhiro\| Tazawa, Hiroshi\| Fujisawa, Masayoshi\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	Colorectal cancer Microsatellite stable Hypoxia-inducible factor Immune checkpoint inhibitors
Note	The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00262-025-04067-3\|
Published Date	2025-05-09
Publication Title	Cancer Immunology, Immunotherapy
Volume	volume74
Issue	issue7
Publisher	Springer
Start Page	192
ISSN	0340-7004
NCID	AA00598499
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	40343532
DOI	10.1007/s00262-025-04067-3
Web of Science KeyUT	001485530100001
Related Url	isVersionOf https://doi.org/10.1007/s00262-025-04067-3

SPRED2 Is a Novel Regulator of Autophagy in Hepatocellular Carcinoma Cells and Normal Hepatocytes

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Author	Wang, Tianyi\| Gao, Tong\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Sakaguchi, Masakiyo\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	autophagy mitophagy SPRED proteins MAPK/ERK mTOR hepatocellular carcinoma
Published Date	2024-06-06
Publication Title	International Journal of Molecular Sciences
Volume	volume25
Issue	issue11
Publisher	MDPI
Start Page	6269
ISSN	1661-6596
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	©2024 by the authors.
File Version	publisher
DOI	10.3390/ijms25116269
Web of Science KeyUT	001245555700001
Related Url	isVersionOf https://doi.org/10.3390/ijms25116269

The specific shapes of capillaries are associated with worse prognosis in patients with invasive breast cancer

FullText URL	fulltext.pdf
Author	Swe, Hnin‐Wint‐Wint\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Komatsubara, Yu\| Yoshimura, Teizo\| Shien, Tadahiko\| Matsukawa, Akihiro\|
Keywords	angiogenesis blood vessels breast cancer CD31 antigen immunohistochemistry microvessel density survival analysis
Published Date	2024-05-31
Publication Title	Pathology International
Volume	volume74
Issue	issue7
Publisher	Wiley
Start Page	394
End Page	407
ISSN	1320-5463
NCID	AA10984364
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 The Author(s).
File Version	publisher
PubMed ID	38818885
DOI	10.1111/pin.13442
Web of Science KeyUT	001235649700001
Related Url	isVersionOf https://doi.org/10.1111/pin.13442

The chemokine monocyte chemoattractant protein-1/CCL2 is a promoter of breast cancer metastasis

FullText URL	fulltext20230621-01.pdf
Author	Yoshimura, Teizo\| Li, Chunning\| Wang, Yuze\| Matsukawa, Akihiro\|
Keywords	Breast cancer chemokines chemokine receptors metastasis macrophages
Note	The version of record of this article, first published in Cellular & Molecular Immunology, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41423-023-01013-0\|
Published Date	2023-05-19
Publication Title	Cellular & Molecular Immunology
Volume	volume20
Issue	issue7
Publisher	Springer Science and Business Media LLC
Start Page	714
End Page	738
ISSN	2042-0226
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2023
File Version	publisher
PubMed ID	37208442
DOI	10.1038/s41423-023-01013-0
Web of Science KeyUT	000990897000001
Related Url	isVersionOf https://doi.org/10.1038/s41423-023-01013-0

SPRED2: A Novel Regulator of Epithelial-Mesenchymal Transition and Stemness in Hepatocellular Carcinoma Cells

FullText URL	fulltext.pdf
Author	Gao, Tong\| Yang, Xu\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Wang, Tianyi\| Tomonobu, Nahoko\| Sakaguchi, Masakiyo\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	cancer stem cells epithelial-mesenchymal transition ERK1/2-MAPK tumorigenesis
Published Date	2023-03-05
Publication Title	International Journal of Molecular Sciences
Volume	volume24
Issue	issue5
Publisher	MDPI
Start Page	4996
ISSN	1422-0067
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 by the authors.
File Version	publisher
PubMed ID	36902429
DOI	10.3390/ijms24054996
Web of Science KeyUT	000947675000001
Related Url	isVersionOf https://doi.org/10.3390/ijms24054996

Highly Metastatic Subpopulation of TNBC Cells Has Limited Iron Metabolism and Is a Target of Iron Chelators

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Author	Wang, Yuze\| Ohara, Toshiaki\| Chen, Yuehua\| Hamada, Yusuke\| Li, Chunning\| Fujisawa, Masayoshi\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	triple-negative breast cancer iron metabolism iron chelator phosphoinositide-3-kinase-protein kinase heterogeneity metastasis
Published Date	2023-01-12
Publication Title	Cancers
Volume	volume15
Issue	issue2
Publisher	MDPI
Start Page	468
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 by the authors.
File Version	publisher
PubMed ID	36672419
DOI	10.3390/cancers15020468
Web of Science KeyUT	000914513700001
Related Url	isVersionOf https://doi.org/10.3390/cancers15020468

Exosomal Wnt7a from a low metastatic subclone promotes lung metastasis of a highly metastatic subclone in the murine 4t1 breast cancer

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Author	Li, Chunning\| Yoshimura, Teizo\| Tian, Miao\| Wang, Yuze\| Kondo, Takamasa\| Yamamoto, Ken-Ichi\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Sakaguchi, Masakiyo\| Matsukawa, Akihiro\|
Keywords	Breast cancer Metastasis Exosomes Epithelial mesenchymal transition Tumor microenvironment
Published Date	2022-09-12
Publication Title	Breast Cancer Research
Volume	volume24
Issue	issue1
Publisher	BMC
Start Page	60
ISSN	1465-5411
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022.
File Version	publisher
PubMed ID	36096830
DOI	10.1186/s13058-022-01557-5
Web of Science KeyUT	000853036400001
Related Url	isVersionOf https://doi.org/10.1186/s13058-022-01557-5

Thioredoxin interacting protein protects mice from fasting induced liver steatosis by activating ER stress and its downstream signaling pathways

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Author	Miyahara, Hiroyuki\| Hasegawa, Kosei\| Yashiro, Masato\| Ohara, Toshiaki\| Fujisawa, Masayoshi\| Yoshimura, Teizo\| Matsukawa, Akihiro\| Tsukahara, Hirokazu\|
Published Date	2022-03-21
Publication Title	Scientific Reports
Volume	volume12
Issue	issue1
Publisher	Nature Portfolio
Start Page	4819
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022
File Version	publisher
PubMed ID	35314758
DOI	10.1038/s41598-022-08791-z
Web of Science KeyUT	000771589000002
Related Url	isVersionOf https://doi.org/10.1038/s41598-022-08791-z

Expression of Spred2 in the urothelial tumorigenesis of the urinary bladder

FullText URL	fulltext.pdf
Author	Oda, Shinsuke\| Fujisawa, Masayoshi\| Li, Chunning\| Ito, Toshihiro\| Yamaguchi, Takahiro\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Published Date	2021-11-24
Publication Title	Plos One
Volume	volume16
Issue	issue11
Publisher	Public Library Science
Start Page	e0254289
ISSN	1932-6203
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 Oda et al.
File Version	publisher
PubMed ID	34818323
DOI	10.1371/journal.pone.0254289
Web of Science KeyUT	000747234800004
Related Url	isVersionOf https://doi.org/10.1371/journal.pone.0254289

Spred2 controls the severity of Concanavalin A-induced liver damage by limiting interferon-gamma production by CD4(+) and CD8(+) T cells

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Author	Sun, Cuiming\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Liu, Qiuying\| Cao, Chen\| Yang, Xu\| Yoshimura, Teizo\| Kunkel, Steven L.\| Matsukawa, Akihiro\|
Keywords	Liver damage MAPK Signal transduction and regulation Gene-modified mice Spred2
Published Date	2022-01
Publication Title	Journal Of Advanced Research
Volume	volume35
Publisher	Elsevier
Start Page	71
End Page	86
ISSN	2090-1232
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 The Authors.
File Version	publisher
PubMed ID	35003795
DOI	10.1016/j.jare.2021.03.014
Web of Science KeyUT	000736947300007
Related Url	isVersionOf https://doi.org/10.1016/j.jare.2021.03.014

Crosstalk between Cancer Cells and Fibroblasts for the Production of Monocyte Chemoattractant Protein-1 in the Murine 4T1 Breast Cancer

FullText URL	fulltext.pdf
Author	Imamura, Mayu\| Li, Tiantian\| Li, Chunning\| Fujisawa, Masayoshi\| Mukaida, Naofumi\| Matsukawa, Akihiro\| Yoshimura, Teizo\|
Keywords	breast cancer chemokine lung metastasis fibroblasts macrophages tumor microenvironment
Published Date	2021-10-22
Publication Title	Current Issues In Molecular Biology
Volume	volume43
Issue	issue3
Publisher	MDPI
Start Page	1726
End Page	1740
ISSN	1467-3037
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 by the authors.
File Version	publisher
PubMed ID	34698088
DOI	10.3390/cimb43030122
Web of Science KeyUT	000735852200001
Related Url	isVersionOf https://doi.org/10.3390/cimb43030122

PolyI:C suppresses TGF-β1-induced Akt phosphorylation and reduces the motility of A549 lung carcinoma cells

FullText URL	fulltext20210824-3.pdf
Author	Yamaguchi, Takahiro\| Yoshimura, Teizo\| Ohara, Toshiaki\| Fujisawa, Masayoshi\| Tong, Gao\| Matsukawa, Akihiro\|
Keywords	Toll-like receptors cell migration metastasis epithelial mesenchymal transformation
Note	This is a post-peer-review, pre-copyedit version of an article published in Molecular Biology Reports. The final authenticated version is available online at: https://doi.org/10.1007/s11033-021-06625-1\|
Published Date	2021-8-14
Publication Title	Molecular Biology Reports
Publisher	Springer Science and Business Media LLC
ISSN	0301-4851
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	34390443
DOI	10.1007/s11033-021-06625-1
Web of Science KeyUT	000684897400002
Related Url	isVersionOf https://doi.org/10.1007/s11033-021-06625-1

Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin

FullText URL	fulltext.pdf
Author	Kawara, Akina\| Mizuta, Ryo\| Fujisawa, Masayoshi\| Ito, Toshihiro\| Li, Chunning\| Nakamura, Kaoru\| Sun, Cuiming\| Kuwabara, Masaki\| Kitabatake, Masahiro\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	Cell signalling Mechanisms of disease
Published Date	2020-10-05
Publication Title	Scientific Reports
Volume	volume10
Issue	issue1
Publisher	Nature
Start Page	16490
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2020
File Version	publisher
PubMed ID	33020583
DOI	10.1038/s41598-020-73752-3
Web of Science KeyUT	000577291800001
Related Url	isVersionOf https://doi.org/10.1038/s41598-020-73752-3

Decreased miR-200b-3p in cancer cells leads to angiogenesis in HCC by enhancing endothelial ERG expression

FullText URL	fulltext.pdf
Author	Moh-Moh-Aung, Aye\| Fujisawa, Masayoshi\| Ito, Sachio\| Katayama, Hiroshi\| Ohara, Toshiaki\| Ota, Yoko\| Yoshimura, Teizo\| Matsukawa, Akihiro\|
Keywords	Molecular medicine Tumour angiogenesis
Published Date	2020-06-26
Publication Title	Scientific Reports
Volume	volume10
Issue	issue1
Publisher	Nature
Start Page	10418
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2020
File Version	publisher
PubMed ID	32591615
DOI	10.1038/s41598-020-67425-4
Web of Science KeyUT	000545967200015
Related Url	isVersionOf https://doi.org/10.1038/s41598-020-67425-4

Cancer Cell-Derived Granulocyte-Macrophage Colony-Stimulating Factor Is Dispensable for the Progression of 4T1 Murine Breast Cancer

FullText URL	fulltext.pdf
Author	Yoshimura, Teizo\| Nakamura, Kaoru\| Li, Chunning\| Fujisawa, Masayoshi\| Shiina, Tsuyoshi\| Imamura, Mayu\| Li, Tiantian\| Mukaida, Naofumi\| Matsukawa, Akihiro\|
Keywords	macrophages chemokines cytokines inflammation tumor microenvironment breast cancer
Published Date	2019-12-16
Publication Title	International Journal of Molecular Sciences
Volume	volume20
Issue	issue24
Publisher	MDPI
ISSN	1422-0067
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2019 by the authors.
File Version	publisher
PubMed ID	31888216
DOI	10.3390/ijms20246342
Web of Science KeyUT	000506840100235
Related Url	isVersionOf https://doi.org/10.3390/ijms20246342