ID | 65298 |
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Author |
Yoshihara, Kumiko
Department of Pathology & Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Nagaoka, Noriyuki
Advanced Research Center for Oral and Craniofacial Science, Okayama University Dental School
Makita, Yoji
National Institute of Advanced Industrial Science and Technology (AIST), Health and Medical Research Institute
Yoshida, Yasuhiro
Department of Biomaterials and Bioengineering, Faculty of Dental Medicine, Hokkaido University
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Van Meerbeek, Bart
Department of Oral Health Sciences, BIOMAT & UZ Leuven (University Hospitals Leuven), Dentistry, KU Leuven (University of Leuven)
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Abstract | Despite being able to adhesively restore teeth, adhesives and cement do not possess any anticariogenic protection potential, by which caries recurrence may still occur and reduce the clinical lifetime of adhesive restorations. Several antibacterial agents have been incorporated into dental adhesives and cement to render them anticariogenic. Due to an additional therapeutic effect, such materials are classified as 'dental combination products' with more strict market regulations. We incorporated cetylpyridinium chloride (CPC), often used for oral hygiene applications, into montmorillonite (CPC-Mont), the latter to serve as a carrier for controlled CPC release. CPC-Mont incorporated into tissue conditioner has been approved by the Pharmaceuticals and Medical Devices Agency (PmontMDA) in Japan. To produce a clinically effective dental cement with the antibacterial potential to prevent secondary caries, we incorporated CPC-Mont into PMMA resin cement. We measured the flexural strength, shear bond strength onto dentin, CPC release, and the biofilm-inhibition potential of the experimental CPC-Mont-containing PMMA cement. An 8 and 10 wt% CPC-Mont concentration revealed the antibacterial potential without reducing the mechanical properties of the PMMA cement.
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Keywords | biofilm
cetylpyridinium chloride
montmorillonite
PMMA resin cement
antibacterial agents
dentin
bond strength
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Published Date | 2023-04-27
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Publication Title |
Nanomaterials
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Volume | volume13
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Issue | issue9
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Publisher | MDPI
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Start Page | 1495
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ISSN | 2079-4991
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © 2023 by the authors.
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File Version | publisher
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Related Url | isVersionOf https://doi.org/10.3390/nano13091495
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License | https://creativecommons.org/licenses/by/4.0/
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Citation | Yoshihara, K.; Nagaoka, N.; Makita, Y.; Yoshida, Y.; Van Meerbeek, B. Long-Term Antibacterial Efficacy of Cetylpyridinium Chloride- Montmorillonite Containing PMMA Resin Cement. Nanomaterials 2023, 13, 1495. https://doi.org/10.3390/ nano13091495
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Funder Name |
Japan Society for the Promotion of Science
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助成番号 | JP18K17068
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