ID | 52139 |
JaLCDOI | |
FullText URL | |
Author |
Moritou, Yuki
Baba, Nobuyuki
Takaguchi, Kouichi
Senoh, Tomonori
Nagano, Takuya
Takeuchi, Yasuto
Yasunaka, Tetsuya
Ohnishi, Hideki
Miyake, Yasuhiro
Kaken ID
|
Abstract | The impact of hepatic steatosis on interferon therapy for patients with chronic hepatitis C (CHC) has been associated with single-nucleotide polymorphisms (SNP) of IL28B, patatin-like phospholipase domain-containing protein 3 (PNPLA3), and low-density lipoprotein (LDL) receptor. Whether this holds true for Japanese patients, however, remains unresolved. The present study prospectively enrolled 226 Japanese patients with CHC, and investigated the impact of hepatic steatosis and its related SNPs, including rs8099917 of IL28B, rs738409 of PNPLA3, and rs14158 of LDL receptor, on outcomes of peg-interferon and ribavirin therapy. In multivariate logistic regression analysis, significant factors affecting the severity of hepatic steatosis were high body mass index and the minor alleles of IL28B SNP (p=0.020 and 0.039, respectively). The risk alleles of PNPLA3 SNP also showed weak association
(p=0.059). Severe steatosis and the minor alleles of IL28B SNP were significantly associated with null or partial virological response in patients with HCV genotype 1, as were female gender, and low LDL cholesterol (p=0.049, and <0.001, respectively). The SNP genotype of PNPLA3 and LDL receptor
did not have a significant impact on therapeutic outcomes. With respect to the SNP sites examined, the SNP of PNPLA3 has a weak association with severe hepatic steatosis, but not with the outcome of interferon therapy.
|
Keywords | hepatic steatosis
genetic polymorphism
interferon
HCV
|
Amo Type | Original Article
|
Publication Title |
Acta Medica Okayama
|
Published Date | 2014-02
|
Volume | volume68
|
Issue | issue1
|
Publisher | Okayama University Medical School
|
Start Page | 17
|
End Page | 22
|
ISSN | 0386-300X
|
NCID | AA00508441
|
Content Type |
Journal Article
|
language |
English
|
Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School
|
File Version | publisher
|
Refereed |
True
|
PubMed ID | |
Web of Science KeyUT |