Prevalence, Characteristics, and Arrhythmogenic Substrate of Mitral Annular Disjunction Assessed by Cardiac Magnetic Resonance Imaging in Patients With Apparently Idiopathic Ventricular Arrhythmia

Asada, Saori; Morita, Hiroshi; Toh, Norihisa; Masuda, Takuro; Ueoka, Akira; Miyamoto, Masakazu; Nakagawa, Koji; Nishii, Nobuhiro; Nakamura, Kazufumi; Yuasa, Shinsuke

doi:10.1002/joa3.70172

Permalink : https://ousar.lib.okayama-u.ac.jp/69120

ID	69120
FullText URL	fulltext.pdf 532 KB
Author	Asada, Saori Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine and Dentistry ORCID Morita, Hiroshi Department of Cardiovascular Therapeutics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap Toh, Norihisa Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine and Dentistry Kaken ID researchmap Masuda, Takuro Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine and Dentistry Ueoka, Akira Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine and Dentistry Miyamoto, Masakazu Department of Cardiology, Kagawa Prefectural Central Hospital Nakagawa, Koji Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine and Dentistry Nishii, Nobuhiro Kaken ID publons Nakamura, Kazufumi Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine and Dentistry Kaken ID publons researchmap Yuasa, Shinsuke Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine and Dentistry
Abstract	Background: Mitral annular disjunction (MAD) is linked to an increased risk of sudden cardiac death, but its association with ventricular arrhythmias (VAs) in Japanese patients is unclear. Methods: We retrospectively analyzed 129 Japanese patients with VAs and no overt structural heart disease who underwent echocardiography and cardiac MRI. Results: MAD was diagnosed in 7.0%, and in 14% of patients with VAs originating from the mitral valve apparatus. MAD was significantly associated with multifocal VAs, late gadolinium enhancement in the papillary muscles, and greater mitral regurgitation. Conclusion: MAD may be an important arrhythmogenic substrate in apparently idiopathic VAs among Japanese patients.
Keywords	arrhythmic mitral valve prolapses idiopathic ventricular arrhythmia late gadolinium enhancement mitral annular disjunction multifocal ventricular arrhythmia
Published Date	2025-08
Publication Title	Journal of Arrhythmia
Volume	volume41
Issue	issue4
Publisher	Wiley
Start Page	e70172
ISSN	1880-4276
NCID	AA12059301
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Author(s).
File Version	publisher
DOI	10.1002/joa3.70172
Related Url	isVersionOf https://doi.org/10.1002/joa3.70172
License	http://creativecommons.org/licenses/by-nc-nd/4.0/
Citation	S. Asada, H. Morita, N. Toh, et al., “ Prevalence, Characteristics, and Arrhythmogenic Substrate of Mitral Annular Disjunction Assessed by Cardiac Magnetic Resonance Imaging in Patients With Apparently Idiopathic Ventricular Arrhythmia,” Journal of Arrhythmia 41, no. 4 (2025): e70172, https://doi.org/10.1002/joa3.70172.