ID | 60741 |
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Author |
Paul, Subha Sankar
Collaborative Research Center of Okayama University for Infectious Diseases in India
Takahashi, Eizo
Department of Health Pharmacy, Yokohama University of Pharmacy
Chowdhury, Goutam
National Institute of Cholera and Enteric Diseases
Miyoshi, Shin-ichi
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences of Okayama University
Mizuno, Tamaki
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences of Okayama University
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Mukhopadhyay, Asish K.
National Institute of Cholera and Enteric Diseases
Dutta, Shanta
National Institute of Cholera and Enteric Diseases
Okamoto, Keinosuke
Collaborative Research Center of Okayama University for Infectious Diseases in India
Kaken ID
publons
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Abstract | It has been well known that Vibrio cholerae inhabit in environmental water. As many patients infected with cholera toxin-producing V. cholerae O1 (toxigenic V. cholerae O1) emerge in Kolkata, India, it has been thought that toxigenic V. cholerae O1 is easily detected in environmental water in Kolkata. However, we could not isolate toxigenic V. cholerae O1 from environmental water in Kolkata, though NAG Vibrio (generic name of V. cholerae non-O1/non-O139) is constantly detected. To clear the reason for the non-isolation of toxigenic V. cholerae O1, we examined the viability of V. cholera O1 and NAG Vibrios in the artificial low ionic strength aquatic solution. We found that the viability of toxigenic V. cholerae O1 in the solution is low, but that of NAG Vibrios is high. Subsequently, we examined the viability of NAG Vibrios possessing cholera toxin gene (ctx) in the same condition and found that the viability of these NAG Vibrios is low. These results indicate that the existence of ctx in V. cholerae affects the viability of V. cholerae in the aquatic solution used in this experiment. We thought that there was closely relation between the low viability of toxigenic V. cholerae O1 in the artificial low ionic strength aquatic solution and the low frequency of isolation of the strain from environmental water.
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Keywords | Vibrio cholerae
cholera toxin
aquatic solution
viability
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Published Date | 2020-08
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Publication Title |
Biological and Pharmaceutical Bulletin
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Volume | volume43
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Issue | issue8
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Publisher | Pharmaceutical Society of Japan
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Start Page | 1288
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End Page | 1291
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ISSN | 0918-6158
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NCID | AA10885497
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © 2020 The Pharmaceutical Society of Japan
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File Version | publisher
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Related Url | isVersionOf https://doi.org/10.1248/bpb.b20-00350
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Funder Name |
Japan Agency for Medical Research and Development
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助成番号 | JP18fm0108002
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