ID | 52788 |
JaLCDOI | |
FullText URL | |
Author |
Hinamoto, Norikazu
Saito, Daisuke
Yamasaki, Hiroko
Nasu, Tatsuyo
Watatani, Hiroyuki
Ujike, Haruyo
Kinomura, Masaru
Sonoda, Hikaru
Kanomata, Naoki
Sato, Yasufumi
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Abstract | Experimental studies have demonstrated the involvement of angiogenesis-related factors in the progression of chronic kidney disease (CKD). There have so far been no reports investigating the distribution and clinical roles of Vasohibin-1 (VASH-1), a negative feedback regulator of angiogenesis, in CKD. We recruited 54 Japanese CKD patients and 6 patients who had normal renal tissues excised due to localized renal cell carcinoma. We evaluated the correlations between the renal expression level of VASH-1 and the clinical/histological parameters. VASH-1 was observed in renal endothelial/mesangial cells, crescentic lesions and interstitial inflammatory cells. Significant positive correlations were observed between 1) crescent formation and the number of VASH-1+ cells in the glomerulus
(r=0.48, p=0.001) or cortex (r=0.64, p<0.0001), 2) interstitial cell infiltration and the number of VASH-1+ cells in the cortex (r=0.34, p=0.02), 3) the glomerular VEGFR-2+ area and the number of VASH-1+ cells in the glomerulus (r=0.44, p=0.01) or medulla (r=0.63, p=0.01). These results suggest that the renal levels of VASH-1 may be affected by local inflammation, crescentic lesions and VEGFR-2.
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Keywords | chronic kidney disease
inflammation
Vasohibin-1
VEGF-A
VEGFR-2
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Amo Type | Original Article
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Publication Title |
Acta Medica Okayama
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Published Date | 2014-08
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Volume | volume68
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Issue | issue4
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Publisher | Okayama University Medical School
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Start Page | 219
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End Page | 233
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT | |
Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52824
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