The Efficacy of Rituximab in High-risk Renal Transplant Recipients

Araki, Motoo; Wada, Koichiro; Mitsui, Yosuke; Kubota, Risa; Yoshioka, Takashi; Ariyoshi, Yuichi; Kobayashi, Yasuyuki; Kitagawa, Masashi; Tanabe, Katsuyuki; Sugiyama, Hiroshi; Wada, Jun; Watanabe, Masami; Watanabe, Toyohiko; Hotta, Katsuyuki; Nasu, Yasutomo

ID	54507
JaLCDOI	10.18926/AMO/54507
FullText URL	70_4_295.pdf 1.83 MB
Author	Araki, Motoo Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap Wada, Koichiro Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID researchmap Mitsui, Yosuke Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kubota, Risa Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Yoshioka, Takashi Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Ariyoshi, Yuichi Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kobayashi, Yasuyuki Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID Kitagawa, Masashi Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID Tanabe, Katsuyuki Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap Sugiyama, Hiroshi Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Wada, Jun Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap Watanabe, Masami Center for Innovative Clinical Medicine, Okayama University Hospital Kaken ID publons researchmap Watanabe, Toyohiko Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap Hotta, Katsuyuki Center for Innovative Clinical Medicine, Okayama University Hospital Kaken ID publons researchmap Nasu, Yasutomo Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID publons researchmap
Abstract	Although graft survival following renal transplantation (RTx) has improved, outcomes following highrisk RTx are variable. Preexisting antibodies, including donor-specific antibodies (DSA), play an important role in graft dysfunction and survival. We have designed a study to investigate the safety and efficacy of anti-CD20 monoclonal antibodies (rituximab) in high-risk RTx recipients. Major eligibility criteria include: 1) major and minor ABO blood group mismatch, 2) positive DSA. Thirty-five patients will receive 200 mg/body of rituximab. The primary endpoint is the incidence of B cell depletion. This study will clarify whether rituximab is efficacious in improving graft survival in high-risk RTx recipients.
Keywords	end-stage renal disease immunosuppression kidney transplantation
Amo Type	Clinical Study Protocols
Publication Title	Acta Medica Okayama
Published Date	2016-08
Volume	volume70
Issue	issue4
Publisher	Okayama University Medical School
Start Page	295
End Page	297
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2016 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	27549676
Web of Science KeyUT	000384748600011