ID | 59917 |
FullText URL | |
Author |
Ohtsuki, Takashi
Department of Medical Technology, Graduate School of Health Sciences, Okayama University
ORCID
Kaken ID
publons
researchmap
Hatipoglu, Omer F.
Department of Medical Technology, Graduate School of Health Sciences, Okayama University
Asano, Keiichi
Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Inagaki, Junko
Department of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
publons
researchmap
Nishida, Keiichiro
Department of Orthopaediac Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
publons
researchmap
Hirohata, Satoshi
Department of Medical Technology, Graduate School of Health Sciences, Okayama University
ORCID
Kaken ID
publons
researchmap
|
Abstract | In patients with osteoarthritis (OA), there is a decrease in both the concentration and molecular size of hyaluronan (HA) in the synovial fluid and cartilage. Cell migration-inducing hyaluronidase 1 (CEMIP), also known as hyaluronan (HA)-binding protein involved in HA depolymerization (HYBID), was recently reported as an HA depolymerization-related molecule expressed in the cartilage of patients with OA. However, the underlying mechanism of CEMIP regulation is not well understood. We found that CEMIP expression was transiently increased by interleukine-1 beta (IL-1 beta) stimulation in chondrocytic cells. We also observed that ERK activation and NF-kappa B nuclear translocation were involved in the induction of CEMIP by IL-1 beta. In addition, both administration of HA and mechanical strain attenuated the CEMIP induction in IL-1 beta-stimulated chondrocytes. In conclusion, we clarified the regulatory mechanism of CEMIP in chondrocytes by inflammatory cytokines and suggested the potential involvement in osteoarthritis development.
|
Keywords | cell migration-inducing hyaluronidase 1 (CEMIP)
chondrocyte
hyaluronan
mechanical strain
nuclear factor kappa B (NF-kappa B)
osteoarthritis
|
Published Date | 2020-04-29
|
Publication Title |
International Journal of Molecular Sciences
|
Volume | volume21
|
Issue | issue9
|
Publisher | MDPI
|
Start Page | 3140
|
ISSN | 1422-0067
|
Content Type |
Journal Article
|
language |
English
|
OAI-PMH Set |
岡山大学
|
Copyright Holders | © 2020 by the authors.
|
File Version | publisher
|
PubMed ID | |
DOI | |
Web of Science KeyUT | |
Related Url | isVersionOf https://doi.org/10.3390/ijms21093140
|
License | http://creativecommons.org/licenses/by/4.0/
|
Funder Name |
Japan Society for the Promotion of Science
|
助成番号 | 17K19727
17H04313
19K09627
19K11791
|