ID | 30384 |
JaLCDOI | |
FullText URL | |
Author |
Inoue, Hajime
Toda, Kazukiyo
Murakami, Takuro
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Abstract | Localization of the glycosaminoglycans (GAG) was examined in the synovial membranes of patients with osteoarthritis under light microscopy using a fine cationic colloidal iron staining method combined with enzymatic digestion. Our staining method was very useful for demonstrating the difference in the localization of GAG in regions of the inflammatory site in the osteoarthritic synovial membrane. Hyaluronic acid was mainly located in connective tissues in the surface intercellular and perivascular spaces, chondroitin sulfate A/C in the highly fibrous part of and connective tissue around blood vessels, dermatan sulfate (chondroitin sulfate B) in the subsurface interstitium and vascular endothelial cells and heparan sulfate in part of vascular endothelial cells. No keratan sulfate was detected. GAG is reported to have an important role in cell movement, adherence and aggregation in the inflammatory sites. These findings should be useful for understanding the role of GAG in physiological and pathologic processes of secondary synovitis. |
Keywords | glycosaminoglycan
synovial tissue
osteoarthritis
fine cationic colloidal iron
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Amo Type | Article
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Publication Title |
Acta Medica Okayama
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Published Date | 1995-12
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Volume | volume49
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Issue | issue6
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Publisher | Okayama University Medical School
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Start Page | 287
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End Page | 294
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |