| JaLCDOI | 10.18926/AMO/31982 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Yumoto, Akihisa| Kusano, Kengo Fukushima| Nakamura, Kazufumi| Hashimoto, Katsushi| Aoki, Motokuni| Morishita, Ryuichi| Kaneda, Yasufumi| Ohe, Tohru| |
| Abstract | It was recently reported that gene therapy using hepatocyte growth factor (HGF) has the potential to preserve cardiac function after myocardial ischemia. We speculated that this HGF gene therapy could also prevent ventricular arrhythmia. To investigate this possibility, we examined the antiarrhythmic effect of HGF gene therapy in rat acute and old myocardial infarction models. Myocardial ischemia was induced by ligation of the left descending coronary artery. Hemagglutinating virus of Japan (HVJ)-coated liposome containing HGF genes were injected directly into the myocardium fourteen days before programmed pacing. Ventricular fibrillation (VF)was induced by programmed pacing. The VF duration was reduced and the VF threshold increased after HGF gene therapy ( p< 0.01). Histological analyses revealed that the number of vessels in the ischemic border zone was greatly increased after HGF gene injection. These findings revealed that HGF gene therapy has an anti-arrhythmic effect after myocardial ischemia. |
| Keywords | ventricular arrhythmia HGF (hepatocyte growth factor) ischemia HVJ (hemagglutinating virus of Japan) |
| Amo Type | Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2005-06 |
| Volume | volume59 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 73 |
| End Page | 78 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 16049559 |
| Web of Science KeyUT | 000230039100001 |
| Author | 中村 一文| 草野 研吾| 垣下 幹夫| 三浦 綾| 久松 研一| 西井 伸洋| 伴場 主一| 渡邊 敦之| 藤尾 栄起| 宮地 克維| 永瀬 聡| 森田 宏| 斎藤 博則| 江森 哲郎| 浅沼 幹人| 宮崎 正博| 中村 陽一| 松原 広己| 伏見 和郎| 豊國 伸哉| 大江 透| |
|---|---|
| Published Date | 2004-05-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume116 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | 武田 昌也| 大塚 文男| 中村 一文| 稲垣 兼一| 鈴木 二郎| 三浦 大志| 藤尾 栄起| 松原 広己| 伊達 洋至| 大江 透| 槇野 博史| |
|---|---|
| Published Date | 2006-05-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume118 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Watanabe, Atsuyuki| Kusano Fukushima, Kengo| Morita, Hiroshi| Miura, Daiji| Sumida, Wakako| Hiramatsu, Shigeki| Banba, Kimikazu| Nishii, Nobuhiro| Nagase, Satoshi| Nakamura, Kazufumi| Sakuragi, Satoru| Ohe, Tohru| |
|---|---|
| Published Date | 2008-05-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume120 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | 中村 一文| |
|---|---|
| Published Date | 1998-09-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
