| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakamura, Kazufumi| Akagi, Satoshi| Ejiri, Kentaro| Yoshida, Masashi| Miyoshi, Toru| Toh, Norihisa| Nakagawa, Koji| Takaya, Yoichi| Matsubara, Hiromi| Ito, Hiroshi| |
| Keywords | pulmonary arterial hypertension prostaglandin I-2 nitric oxide endothelin |
| Published Date | 2019-11-23 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume20 |
| Issue | issue23 |
| Publisher | MDPI |
| Start Page | 5885 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 by the authors. |
| File Version | publisher |
| PubMed ID | 31771203 |
| DOI | 10.3390/ijms20235885 |
| Web of Science KeyUT | 000504428300067 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms20235885 |
| JaLCDOI | 10.18926/AMO/54600 |
|---|---|
| FullText URL | 70_5_397.pdf |
| Author | Akagi, Satoshi| Nakamura, Kazufumi| Akagi, Teiji| Nakagawa, Koji| Takaya, Yoichi| Sarashina, Toshihiro| Ejiri, Kentaro| Ito, Hiroshi| |
| Abstract | A treatment strategy for patients with pulmonary hypertension (PH) and atrial septal defect (ASD) remains unclear. This study was designed to evaluate the effects of initial repair of ASD followed by treatment with PH-specific drugs in patients with PH and ASD. Eligible patients receive transcatheter ASD closure followed by treatment with bosentan and sildenafil. Right heart catheterization is performed at baseline and at 12, 24 and 48 weeks. The primary endpoint is change in pulmonary artery pressure and pulmonary vascular resistance from baseline to follow-up. This study should provide valuable information to establish a therapeutic strategy for PH and ASD. |
| Keywords | pulmonary hypertension atrial septal defect repair and treat transcatheter closure |
| Amo Type | Clinical Study Protocols |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-10 |
| Volume | volume70 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 397 |
| End Page | 400 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27777434 |
| Web of Science KeyUT | 000388098700011 |
