| ID | 34207 |
| FullText URL | |
| Author |
Ali, Hamed I..
Tomita, Keiichiro
Akaho, Eiichi
Kambara, Hiroto
Miura, Shinji
Hayakawa, Hiroyuki
Ashida, Noriyuki
Kawashima, Yutaka
Yamagishi, Takehiro
Ikeya, Hisao
Yoneda, Fumio
|
| Abstract | Novel 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides were prepared as a new class of antitumor agents and showed significant antitumor activities against NCI-H 460, HCT 116, A 431, CCRF-HSB-2, and KB cell lines. In vivo investigation, 2-deoxo-10-methyl-2-phenyl-5-deazaflavin exhibited the effective antitumor activity against A 431 human adenocarcinoma cells transplanted subcutaneously into nude mouse. Furthermore, AutoDock study has been done by binding of the flavin analogs into PTK pp60(c-src), where a good correlation between their IC50 and AutoDock binding free energy was exhibited. In particular, 2-deoxo-2-phenylflavin-5-oxides exhibited the highest potential binding affinity within the binding pocket of PTK.
|
| Keywords | antitumor activity
Flavin analog
AutoDock
protein tyrosine kinase
|
| Note | Published with permission from the copyright holder.
This is a author's copy,as published in Bioorganic & Medicinal Chemistry , 2007 Vol.15 Issue.1 pp.242-256 Publisher URL: http://dx.doi.org/10.1016/j.bmc.2006.09.063 Direct access to Thomson Web of Science record Copyright © 2007 by Elsevier Ltd. |
| Published Date | 2007-01-01
|
| Publication Title |
Bioorganic & Medicinal Chemistry
|
| Volume | volume15
|
| Issue | issue1
|
| Publisher | Pergamon-Elsevier Science Ltd.
|
| Start Page | 242
|
| End Page | 256
|
| ISSN | 0968-0896
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| NCID | AA10938083
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| Content Type |
Journal Article
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| language |
English
|
| Copyright Holders | Elsevier Ltd.
|
| File Version | author
|
| Refereed |
True
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| DOI | |
| PubMed ID | |
| Web of Science KeyUT | |
| Submission Path | organic_chemistry/11
|
