ID | 57483 |
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Author |
Yamamoto, Haruchika
Department of General Thoracic Surgery and Breast and Endocrinological SurgeryOkayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Sugimoto, Seiichiro
Department of General Thoracic SurgeryOkayama University Hospital
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Tanaka, Shin
Department of General Thoracic Surgery and Breast and Endocrinological SurgeryOkayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Kurosaki, Takeshi
Department of Organ Transplant CenterOkayama University Hospital
Otani, Shinji
Department of Organ Transplant CenterOkayama University Hospital
Yamane, Masaomi
Department of General Thoracic Surgery and Breast and Endocrinological SurgeryOkayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Taira, Naruto
Department of Breast and Endocrinological SurgeryOkayama University Hospital
Oto, Takahiro
Department of Organ Transplant CenterOkayama University Hospital
Toyooka, Shinichi
Department of General Thoracic Surgery and Breast and Endocrinological SurgeryOkayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
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Abstract | PURPOSE:
Glucocorticoids are used to prevent chronic lung allograft dysfunction (CLAD) after lung transplantation (LT). Our study was aimed at assessing the association between the glucocorticoid-induced transcript 1 gene (GLCCI1) variant, which modulates glucocorticoid sensitivity, and the postoperative lung function and development of CLAD after LT.
METHODS:
A total of 71 recipients of LT were genotyped for the GLCCI1 variant (rs37972) and divided into three groups: the homozygous mutant allele (TT) group, the heterozygous mutant allele (CT) group, and the wild-type allele (CC) group. The results of pulmonary function tests were compared with the postoperative baseline values.
RESULTS:
The total lung capacity (TLC) in the TT group was significantly lower than that in the CC group at 3 years after LT (P = 0.029). In the recipients of cadaveric LT, the TLC and forced expiratory volume in 1 s in the TT group were significantly lower than those in the CC groups, resulting in a significant worse CLAD-free survival at 3 years after LT (P = 0.016).
CONCLUSION:
The GLCCI1 variant was associated with a significant decrease of the TLC at 3 years after LT and the development of CLAD at 3 years, especially in patients undergoing cadaveric LT.
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Keywords | Chronic lung allograft dysfunction
Glucocorticoid
Lung transplantation
Single-nucleotide polymorphism
Total lung capacity
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Note | This fulltext will be available in Dec 2017
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Published Date | 2018-09-18
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Publication Title |
Surgery Today
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Volume | volume49
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Issue | issue3
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Publisher | Springer
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Start Page | 268
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End Page | 274
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ISSN | 09411291
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NCID | AA10824685
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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File Version | author
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Related Url | isVersionOf https://doi.org/10.1007/s00595-018-1717-9
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License | https://creativecommons.org/licenses/by-nc-nd/4.0/
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Citation | Yamamoto, H., Sugimoto, S., Tanaka, S. et al. Surg Today (2019) 49: 268. https://doi.org/10.1007/s00595-018-1717-9
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Funder Name |
Japan Society for the Promotion of Science
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助成番号 | 15K10256
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