ID | 61473 |
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Author |
Yamamoto, Haruchika
Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
Sugimoto, Seiichiro
Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
ORCID
Kaken ID
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Soh, Junichi
Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
Shiotani, Toshio
Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
Miyoshi, Kentaroh
Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
Kaken ID
Otani, Shinji
Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
Okazaki, Mikio
Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
Yamane, Masaomi
Kaken ID
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Toyooka, Shinichi
Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
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Abstract | Purpose
The prognostic nutritional index (PNI), calculated based on the serum albumin levels and the total lymphocyte count, has been identified as a predictor of clinical outcomes in various fields of surgery. In this study, we investigated the relationship between the PNI and the lung allocation score (LAS) as well as the impact of the PNI on the outcomes of both cadaveric lung transplantation (CLT) and living-donor lobar lung transplantation (LDLLT).
Methods
We reviewed retrospective data for 127 recipients of lung transplantation (LT), including 71 recipients of CLT and 56 recipients of LDLLT.
Results
The PNI was correlated significantly and negatively with the LAS (r = − 0.40, P = 0.0000037). Multivariate analysis revealed that age (P = 0.00093), BMI (P = 0.00087), and PNI (P = 0.0046) were independent prognostic factors of a worse outcome after LT. In a subgroup analysis, survival after both CLT (P = 0.015) and LDLLT (P = 0.041) was significantly worse in the low PNI group than in the high PNI group.
Conclusion
Preoperative nutritional evaluations using the PNI can assist with the assessment of disease severity in LT recipients and may predict survival after both CLT and LDLLT.
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Keywords | Prognostic nutrition index
Lung allocation score
Lung transplantation
Living-donor lobar lung transplantation
Outcome
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Note | This is a post-peer-review, pre-copyedit version of an article published in Surgery Today. The final authenticated version is available online at: https://doi.org/10.1007/s00595-021-02244-2.
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Published Date | 2021-2-13
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Publication Title |
Surgery Today
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Volume | volume51
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Publisher | Springer
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Start Page | 1610
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End Page | 1618
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ISSN | 0941-1291
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NCID | AA10824685
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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File Version | author
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DOI | |
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Related Url | isVersionOf https://doi.org/10.1007/s00595-021-02244-2
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Funder Name |
Japan Society for the Promotion of Science
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助成番号 | 19K09305
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