ID | 65303 |
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Author |
Kawana, Shinichi
Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
Miyoshi, Kentaroh
Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
Kaken ID
Tanaka, Shin
Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
Sugimoto, Seiichiro
Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
ORCID
Kaken ID
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Shimizu, Dai
Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
Matsubara, Kei
Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
Okazaki, Mikio
Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
Hattori, Noboru
Department of Molecular and Internal Medicine, Hiroshima University, Graduate School of Biomedical and Health Sciences
Toyooka, Shinichi
Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
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Abstract | Pulmonary alveolar proteinosis (PAP) affecting transplanted lungs is not well recognized. Herein, we report two cases of PAP after lung transplantation (LTx). The first case was a 4-year-old boy with hereditary pulmonary fibrosis who underwent bilateral LTx and presented with respiratory distress on postoperative day (POD) 23. He was initially treated for acute rejection, died due to infection on POD 248, and was diagnosed with PAP at autopsy. The second case involved a 52-year-old man with idiopathic pulmonary fibrosis who underwent bilateral LTx. On POD 99, chest computed tomography revealed ground-glass opacities. Bronchoalveolar lavage and transbronchial biopsy led to a diagnosis of PAP. Follow-up with immunosuppression tapering resulted in clinical and radiological improvement. PAP after lung transplantation mimics common acute rejection; however, is potentially transient or resolved with tapering immunosuppression, as observed in the second case. Transplant physicians should be aware of this rare complication to avoid misconducting immunosuppressive management.
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Keywords | graft dysfunction
immunosuppression
lung transplantation
pulmonary alveolar proteinosis
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Published Date | 2023-05-23
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Publication Title |
Respirology Case Reports
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Volume | volume11
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Issue | issue6
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Publisher | Wiley
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Start Page | e01160
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ISSN | 2051-3380
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © 2023 The Authors.
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File Version | publisher
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DOI | |
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Related Url | isVersionOf https://doi.org/10.1002/rcr2.1160
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License | https://creativecommons.org/licenses/by-nc-nd/4.0/
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Citation | Kawana, S, Miyoshi, K, Tanaka, S, Sugimoto, S, Shimizu, D, Matsubara, K, et al. Pulmonary alveolar proteinosis after lung transplantation: Two case reports and literature review. Respirology Case Reports. 2023; 11:e01160. https://doi.org/10.1002/rcr2.1160
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Funder Name |
Japan Society for the Promotion of Science
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助成番号 | jp21k08882
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