FullText URL | fulltext20210706-2.pdf |
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Author | Kidani, Naoya| Sugiu, Kenji| Terasaka, Kaoru| Nakashima, Hiroyuki| Tokunaga, Koji| Kobayashi, Kazuki| Kambara, Hirokazu| Hishikawa, Tomohito| Hiramatsu, Masafumi| Date, Isao| |
Note | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00701-021-04885-1| |
Published Date | 2021-6-19 |
Publication Title | Acta Neurochirurgica |
Volume | volume164 |
Issue | issue2 |
Publisher | Springer Science and Business Media LLC |
Start Page | 517 |
End Page | 523 |
ISSN | 0001-6268 |
NCID | AA0050885X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 34146152 |
DOI | 10.1007/s00701-021-04885-1 |
Web of Science KeyUT | 000663495400001 |
Related Url | isVersionOf https://doi.org/10.1007/s00701-021-04885-1 |
JaLCDOI | 10.18926/AMO/32274 |
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FullText URL | fulltext.pdf |
Author | Hirotsune, Nobuyuki| Kinugasa, Kazushi| Mandai, Shinya| Tokunaga, Koji| Handa, Akira| Kawada, Sanami| Ohmoto, Takashi| |
Abstract | Cellulose acetate polymer (CAP) solution is a new liquid embolic material, and it has been used clinically for the thrombosis of cerebral aneurysms. The purpose of the study was to test a method of aneurysm treatment. In an experimental model, retrievable interlocking detachable coils (IDCs) were used to create an intraaneurysmal frame or prop and then CAP was injected into 20 experimentally induced canine cervical aneurysms. Intraaneurysmal thrombosis was induced 1 week after aneurysm creation. Complete thrombosis was attempted in 12 aneurysms, and partial thrombosis was attempted in 4. Four other aneurysms served as controls. Follow-up angiography was performed for up to 8 weeks, and with the exception of 4 aneurysms, which were kept for a 2-year long-term follow-up study, the aneurysms were then harvested for histological examination. Thrombosis was successfully achieved in all cases except for 2 enlarged aneurysms that were initially partially thrombosed. No thromboembolism to distal vessels was observed. No compaction or shift of the CAP-IDC complex occurred even after 2 years. Histologically, CAP and IDCs conformed to the massive thrombotic complex without any fragmentation. By creating a frame or prop with retrievable microcoils, we were able to inject the CAP implies a comparison safely and precisely than has been previously reported. Our findings suggest that this method will be useful for the treatment of cerebral aneurysms. |
Keywords | experimentally induced aneurysm cellulose acetate polymer (CAP) interlocking detachable coil (IDC) endovascular technique |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2000-08 |
Volume | volume54 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 153 |
End Page | 164 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 10985175 |
Web of Science KeyUT | 000089132800003 |
JaLCDOI | 10.18926/AMO/31858 |
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FullText URL | fulltext.pdf |
Author | Ogawa, Tomoyuki| Ono, Shigeki| Ichikawa, Tomotsugu| Arimitsu, Seiji| Onoda, Keisuke| Tokunaga, Koji| Sugiu, Kenji| Tomizawa, Kazuhito| Matsui, Hideki| Date, Isao| |
Abstract | Many studies have shown that a motif of 11 consecutive arginines (11R) is one of the most effective protein transduction domains (PTD) for introducing proteins into the cell membrane. By conjugating this "11R", all sorts of proteins can effectively and harmlessly be transferred into any kind of cell. We therefore examined the transduction efficiency of 11R in cerebral arteries and obtained results showing that 11R fused enhanced green fluorescent protein (11R-EGFP) immediately and effectively penetrated all layers of the rat basilar artery (BA), especially the tunica media. This method provides a revolutionary approach to cerebral arteries and ours is the first study to demonstrate the successful transductionof a PTD fused protein into the cerebral arteries. In this review, we present an outline of our studies and other key studies related to cerebral vasospasm and 11R, problems to be overcome, and predictions regarding future use of the 11R protein transduction method for cerebral vasospasm (CV). |
Keywords | cerebral vasospasm 11 consecutive arginines (11R) enhanced green fluorescent protein (EGFP) |
Amo Type | Review |
Publication Title | Acta Medica Okayama |
Published Date | 2009-02 |
Volume | volume63 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 1 |
End Page | 7 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 19247417 |
Web of Science KeyUT | 000263730300001 |
Title Alternative | Novel protein transduction method for cerebral arteries using 11R |
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FullText URL | 120_129.pdf |
Author | Ogawa, Tomoyuki| Ono, Shigeki| Ichikawa, Tomotsugu| Arimitsu, Seiji| Onoda, Keisuke| Tokunaga, Koji| Sugiu, Kenji| Tomizawa, Kazuhito| Matsui, Hideki| Date, Isao| |
Keywords | cerebral vasospasm 11R protein transduction method |
Publication Title | 岡山医学会雑誌 |
Published Date | 2008-08-01 |
Volume | volume120 |
Issue | issue2 |
Start Page | 129 |
End Page | 133 |
ISSN | 00301558 |
language | Japanese |
Copyright Holders | 岡山医学会 |
File Version | publisher |
DOI | 10.4044/joma.120.129 |
NAID | 120002310545 |
Author | 徳永 浩司| |
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Published Date | 1998-12-31 |
Publication Title | |
Content Type | Thesis or Dissertation |