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ID 65867
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Kanzaki, Hiromitsu Department of Gastroenterology, Okayama University Hospital ORCID publons researchmap
Horii, Joichiro Department of Gastroenterology, Fukuyama Medical Center
Takenaka, Ryuta Department of Internal Medicine, Tsuyama Central Hospital
Nakagawa, Hiroyuki Department of Endoscopy, Hiroshima City Hiroshima Citizens Hospital
Matsueda, Kazuhiro Department of Gastroenterology and Hepatology, Kurashiki Central Hospital
Tsuzuki, Takao Department of Internal Medicine, Himeji Red Cross Hospital
Kita, Masahide Department of Gastroenterology, Okayama City Hospital
Yamasaki, Yasushi Department of Gastroenterology, Okayama University Hospital ORCID Kaken ID publons
Tanaka, Takehiro Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons
Iwamuro, Masaya Department of Gastroenterology, Okayama University Hospital ORCID Kaken ID publons researchmap
Kawano, Seiji Department of Gastroenterology, Okayama University Hospital ORCID
Kawahara, Yoshiro Department of Practical Gastrointestinal Endoscopy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID researchmap
Tomoda, Jun Department of Internal Medicine, Akaiwa Medical Association Hospital
Okada, Hiroyuki Department of Gastroenterology, Okayama University Hospital Kaken ID publons researchmap
Abstract
Background and study aims Because the endoscopic treatment for non-ampullary duodenal adenoma (NADA) has a non-negligible risk of adverse events (AEs), a safe and easy treatment for NADA is desirable. This was a multicenter prospective trial evaluating the efficacy and safety of cold forceps polypectomy (CFP) for diminutive NADAs.
Patients and methods This study was prospectively conducted at six general hospitals and one university hospital. The inclusion criteria were histologic and endoscopic diagnosis of low-grade NADA measuring ≤ 6 mm. A second endoscopy was scheduled for 1 month after CFP. After confirmation of the success of CFP, 6-month and 12-month surveillance endoscopies were scheduled. The primary endpoint was the endoscopic and histologic disease disappearance rates at the 12-month endoscopy.
Results Thirty-nine lesions from 38 patients were prospectively included. Median tumor size at enrollment was 5 mm (range 3–6 mm). There were four cases of remnant lesions at the second endoscopy, and the lesion disappearance rate of single CFP was 89.7 % (35 /39; 95 % confidence interval (CI), 76.9 %–97.9 %). In three cases, complete removal of the lesion was achieved with a single re-CFP, but one case required four repeat CFPs. The lesion disappearance rate at 12-month endoscopy was 97.4 % (38 /39; 95 %CI, 86.8 %–99.5 %). During the follow-up period, no AEs related to CFP were observed.
Conclusions CFP for NADA ≤ 6 mm was safe and effective in this study. This common endoscopic method to remove lesions may be an option for treatment of diminutive NADAs.
Published Date
2022-06-10
Publication Title
Endoscopy International Open
Volume
volume10
Issue
issue06
Publisher
Georg Thieme Verlag KG
Start Page
E712
End Page
E718
ISSN
2364-3722
Content Type
Journal Article
language
English
OAI-PMH Set
岡山大学
Copyright Holders
© 2022. The Author(s).
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isVersionOf https://doi.org/10.1055/a-1793-9439
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https://creativecommons.org/licenses/by-nc-nd/4.0/