ID | 50973 |
FullText URL | |
Author |
Hayashi, Atsushi
Fumon, Takumi
Miki, Yukari
Sato, Hiaki
Yoshino, Tadashi
Takahashi, Kiyoshi
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Abstract | Thymic carcinoma (TC) is often very difficult to distinguish from type B3 thymoma and lung squamous cell carcinoma (L-SCC) involving the anterior mediastinum. The present study evaluated the usefulness of immunohistochemical markers including c-Kit, CD5, glucose transporter-1 (GLUT-1), claudin-1 (CLDN-1), thymoproteasome β5t, p53 and Ki-67 (MIB-1) and thymic cortical environmental marker cells, cortical thymocytes (c-Thy) and thymic cortical dendritic macrophages (TCDMs) in distinguishing thymic carcinoma (TC) from type B3 thymoma or lung squamous cell carcinoma (L-SCC) using 17 cases of type B3 thymoma, 18 cases of TC and 12 cases of L-SCC. The results indicated that c-Kit and CD5 are very useful markers for TC, while GLUT-1, CLDN-1, p53 and Ki-67 are not. Thymic cortical microenvironmental marker cells, especially TCDMs, and thymic cortical epithelial cell-marker β5t are also useful for distinguishing TC from type B3 thymoma. Although none of these markers are adequate for making a distinction when used alone, the plural use of c-Kit, CD5, β5t thymic cortical environmental marker cells, c-Thys and TCDMs may therefore lead to a correct distinction between TC and type B3 thymoma or L-SCC. [J Clin Exp Hematop 53(1) : 9-19, 2013]
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Keywords | thymic carcinoma
type B3 thymoma
lung squamous cell carcinoma
immunohistochemical distinction
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Published Date | 2013-06
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Publication Title |
Journal of Clinical and Experimental Hematopathology
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Volume | volume53
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Issue | issue1
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Start Page | 9
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End Page | 19
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ISSN | 1346-4280
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Content Type |
Journal Article
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Official Url | http://dx.doi.org/10.3960/jslrt.53.9
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Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/50872
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language |
English
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Copyright Holders | © 2013 by The Japanese Society for Lymphoreticular Tissue Research
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File Version | publisher
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Refereed |
True
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DOI | |
PubMed ID |