ID | 32167 |
JaLCDOI | |
FullText URL | |
Author |
Okazaki, Morihiro
Kitani, Hikaru
Mifune, Takashi
Asaumi, Noboru
Tanizaki, Yoshiro
Harada, Hideo
Takahashi, Kiyoshi
Kimura, Ikuro
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Abstract | Serum levels of total IgE, specific IgE, IgG and IgG4 against house dust mite were measured in mite-sensitive asthma patients receiving immunotherapy with house dust. Serum levels of total IgE, mite specific IgE and IgG did not significantly change during the course of hyposensitization. Increased levels of mite specific IgG4 were observed in patients during immunotherapy. The increase in specific IgG4 was dependent on the total dose of house dust administered in both children (r = 0.636, p less than 0.001) and adults (r = 0.629, p less than 0.01). However, the increase of specific IgG4 in adults was not as apparent as in children. These results might suggest that mite specific IgG4 is a useful immunological marker in the immunotherapy for allergic asthma, and that IgG4 antibody acts as a blocking antibody in atopic bronchial asthma. |
Keywords | house dust mite
bronchial asthma
hyposensitization
specific IgG4
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Amo Type | Article
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Publication Title |
Acta Medica Okayama
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Published Date | 1991-08
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Volume | volume45
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Issue | issue4
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Publisher | Okayama University Medical School
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Start Page | 267
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End Page | 273
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |