ID | 64135 |
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Author |
Yokogi, Kyoka
Department of Biology, Graduate School of Natural Science and Technology, Okayama University
Goto, Yuki
Department of Biology, Graduate School of Natural Science and Technology, Okayama University
Otsuka, Mai
Department of Biology, Graduate School of Natural Science and Technology, Okayama University
Ojima, Fumiya
Department of Natural Sciences and Biology, Kawasaki Medical School
Kobayashi, Tomoe
Division of Molecular Genetics, Shigei Medical Research Institute
Tsuchiba, Yukina
Department of Biology, Graduate School of Natural Science and Technology, Okayama University
Takeuchi, Yu
Department of Biology, Graduate School of Natural Science and Technology, Okayama University
Namba, Masumi
Division of Molecular Genetics, Shigei Medical Research Institute
Kohno, Mayumi
Division of Molecular Genetics, Shigei Medical Research Institute
Tetsuka, Minami
Department of Biology, Graduate School of Natural Science and Technology, Okayama University
Takeuchi, Sakae
Department of Biology, Graduate School of Natural Science and Technology, Okayama University
Kaken ID
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Matsuyama, Makoto
Division of Molecular Genetics, Shigei Medical Research Institute
Aizawa, Sayaka
Department of Biology, Graduate School of Natural Science and Technology, Okayama University
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Abstract | Studies in genetically modified mice establish that essential roles of endogenous neuromedin U (NMU) are anorexigenic function and metabolic regulation, indicating that NMU is expected to be a potential target for anti-obesity agents. However, in central administration experiments in rats, inconsistent results have been obtained, and the essential role of NMU energy metabolism in rats remain unclear. This study aims to elucidate the role of endogenous NMU in rats. We generated NMU knockout (KO) rats that unexpectedly showed no difference in body weight, adiposity, circulating metabolic markers, body temperature, locomotor activity, and food consumption in both normal and high fat chow feeding. Furthermore, unlike reported in mice, expressions of Nmu and NMU receptor type 2 (Nmur2) mRNA were hardly detectable in the rat hypothalamic nuclei regulating feeding and energy metabolism, including the arcuate nucleus and paraventricular nucleus, while Nmu was expressed in pars tuberalis and Nmur2 was expressed in the ependymal cell layer of the third ventricle. These results indicate that the species-specific expression pattern of Nmu and Nmur2 may allow NMU to have distinct functions across species, and that endogenous NMU does not function as an anorexigenic hormone in rats.
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Published Date | 2022-10-27
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Publication Title |
Scientific Reports
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Volume | volume12
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Issue | issue1
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Publisher | Nature Portfolio
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Start Page | 17472
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ISSN | 2045-2322
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © The Author(s) 2022
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File Version | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
Related Url | isVersionOf https://doi.org/10.1038/s41598-022-21764-6
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License | http://creativecommons.org/licenses/by/4.0/
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Funder Name |
Ministry of Education, Culture, Sports, Science and Technology
Japan Society for the Promotion of Science
Mishima Kaiun Memorial Foundation
Koyanagi Foundation
Sanyohoso-zaidan
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助成番号 | JP17K1515009
JP20K15833
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